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Protein Ontology report - Rho-related small GTPase
PR:000000122 - http://purl.obolibrary.org/obo/PR_000000122
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000122   
  PRO nameRho-related small GTPase 
  Synonyms
PRO-Short-label: EXACT:fam:RHO
  Definition"A small GTPase with a short insert (approximately 13 residues) coincident with loop 8 of Ras. This insert region forms a highly charged helix without dramatic disturbance of the global structure shared with other small GTPases. Rho-related small GTPases act as key transducers of extracellular signals to regulate the actin cytoskeleton, cell cycle progression and gene expression." [PMID:11463812] 
  PRO Categoryfamily 
  ParentPR:000000028 small GTPase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene14                                                  Organism-Gene 46                                        
         Sequence12                                                  Organism-Sequence 37                                        
         Modification3                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037169
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000122 Rho-related small GTPase, fam:RHO
Yes
gene


PR:000000176 GTP-binding protein RhoA, RHOA

organism-gene


PR:P06780 GTP-binding protein RHO1 (yeast), yRHOA

organism-gene


PR:P48148 Ras-like GTP-binding protein Rho1 (fruit fly), fly-RHOA

organism-gene


PR:P61585 transforming protein RhoA (cow), cow-RHOA

organism-sequence


PR:P61585-1 transforming protein RhoA isoform 1 (cow), cow-RHOA/iso:1

organism-modification


PR:000036521 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 (cow), cow-RHOA/iso:1/IpCysEst:1
Yes
organism-gene


PR:P61586 transforming protein RhoA (human), hRHOA

organism-sequence


PR:P61586-1 transforming protein RhoA isoform 1 (human), hRHOA/iso:1

organism-modification


PR:000036520 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 (human), hRHOA/iso:1/IpCysEst:1
Yes
organism-modification


PR:000084770 transforming protein RhoA cysteinylated 1 (human), hRHOA/Cyst:1

organism-gene


PR:P61589 transforming protein RhoA (rat), rRHOA

organism-gene


PR:Q22038 Ras-like GTP-binding protein rhoA (worm), RHOA (worm)

organism-gene


PR:Q7T2E8 Rho-related GTP-binding protein RhoA-C (zebrafish), z-RHOA

organism-gene


PR:Q9QUI0 transforming protein RhoA (mouse), mRHOA

organism-sequence


PR:Q9QUI0-1 transforming protein RhoA isoform 1 (mouse), mRHOA/iso:1

sequence


PR:000000395 GTP-binding protein RhoA isoform 1, RHOA/iso:1

organism-sequence


PR:P61585-1 transforming protein RhoA isoform 1 (cow), cow-RHOA/iso:1

organism-modification


PR:000036521 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 (cow), cow-RHOA/iso:1/IpCysEst:1
Yes
organism-sequence


PR:P61586-1 transforming protein RhoA isoform 1 (human), hRHOA/iso:1

organism-modification


PR:000036520 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 (human), hRHOA/iso:1/IpCysEst:1
Yes
organism-sequence


PR:Q9QUI0-1 transforming protein RhoA isoform 1 (mouse), mRHOA/iso:1

modification


PR:000000615 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1, RHOA/iso:1/IpCysEst:1

organism-modification


PR:000036520 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 (human), hRHOA/iso:1/IpCysEst:1
Yes
organism-modification


PR:000036521 GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 (cow), cow-RHOA/iso:1/IpCysEst:1
Yes
modification


PR:000018289 GTP-binding protein RhoA proteolytic cleavage product, RHOA/ClvPrd

gene


PR:000013977 Rho-related GTP-binding protein RhoB, RHOB

organism-gene


PR:P62745 Rho-related GTP-binding protein RhoB (human), hRHOB

organism-sequence


PR:P62745-1 Rho-related GTP-binding protein RhoB isoform 1 (human), hRHOB/iso:1

organism-modification


PR:000045846 Rho-related GTP-binding protein RhoB phosphorylated 1 (human), hRHOB/Phos:1

organism-gene


PR:P62746 Rho-related GTP-binding protein RhoB (mouse), mRHOB

organism-sequence


PR:P62746-1 Rho-related GTP-binding protein RhoB isoform 1 (mouse), mRHOB/iso:1

organism-gene


PR:P62747 Rho-related GTP-binding protein RhoB (rat), rRHOB

organism-sequence


PR:P62747-1 Rho-related GTP-binding protein RhoB isoform 1 (rat), rRHOB/iso:1

organism-gene


PR:Q09914 GTP-binding protein rho1 (Schizosaccharomyces pombe 972h-), Spom972h-RHOB

organism-gene


PR:Q23862 Rho-related protein racE (Dictyostelium discoideum), Dicty-RHOB

sequence


PR:000040021 Rho-related GTP-binding protein RhoB isoform 1, RHOB/iso:1

organism-sequence


PR:P62745-1 Rho-related GTP-binding protein RhoB isoform 1 (human), hRHOB/iso:1

organism-sequence


PR:P62746-1 Rho-related GTP-binding protein RhoB isoform 1 (mouse), mRHOB/iso:1

organism-sequence


PR:P62747-1 Rho-related GTP-binding protein RhoB isoform 1 (rat), rRHOB/iso:1

modification


PR:000021264 Rho-related GTP-binding protein RhoB proteolytic cleavage product, RHOB/ClvPrd

gene


PR:000013978 Rho-related GTP-binding protein RhoC, RHOC

organism-gene


PR:P08134 Rho-related GTP-binding protein RhoC (human), hRHOC

organism-sequence


PR:P08134-1 Rho-related GTP-binding protein RhoC isoform 1 (human), hRHOC/iso:1

organism-gene


PR:Q62159 Rho-related GTP-binding protein RhoC (mouse), mRHOC

organism-sequence


PR:Q62159-1 Rho-related GTP-binding protein RhoC isoform 1 (mouse), mRHOC/iso:1

organism-gene


PR:Q9PSX7 Rho-related GTP-binding protein RhoC (chicken), chick-RHOC

organism-sequence


PR:Q9PSX7-1 Rho-related GTP-binding protein RhoC isoform 1 (chicken), chick-RHOC/iso:1

sequence


PR:000038733 Rho-related GTP-binding protein RhoC isoform 1, RHOC/iso:1

organism-sequence


PR:P08134-1 Rho-related GTP-binding protein RhoC isoform 1 (human), hRHOC/iso:1

organism-sequence


PR:Q62159-1 Rho-related GTP-binding protein RhoC isoform 1 (mouse), mRHOC/iso:1

organism-sequence


PR:Q9PSX7-1 Rho-related GTP-binding protein RhoC isoform 1 (chicken), chick-RHOC/iso:1

gene


PR:000013979 Rho-related GTP-binding protein RhoD, RHOD

organism-gene


PR:O00212 Rho-related GTP-binding protein RhoD (human), hRHOD

organism-sequence


PR:O00212-1 Rho-related GTP-binding protein RhoD isoform 1 (human), hRHOD/iso:1

organism-gene


PR:P97348 Rho-related GTP-binding protein RhoD (mouse), mRHOD

organism-sequence


PR:P97348-1 Rho-related GTP-binding protein RhoD isoform 1 (mouse), mRHOD/iso:1

sequence


PR:000037905 Rho-related GTP-binding protein RhoD isoform 1, RHOD/iso:1

organism-sequence


PR:O00212-1 Rho-related GTP-binding protein RhoD isoform 1 (human), hRHOD/iso:1

organism-sequence


PR:P97348-1 Rho-related GTP-binding protein RhoD isoform 1 (mouse), mRHOD/iso:1

gene


PR:000013980 Rho-related GTP-binding protein RhoF, RHOF

organism-gene


PR:Q00245 GTP-binding protein RHO3 (yeast), yRHOF

organism-gene


PR:Q8BYP3 Rho-related GTP-binding protein RhoF (mouse), mRHOF

organism-gene


PR:Q9HBH0 Rho-related GTP-binding protein RhoF (human), hRHOF

organism-sequence


PR:Q9HBH0-1 Rho-related GTP-binding protein RhoF isoform h1 (human), hRHOF/iso:h1

organism-sequence


PR:Q9HBH0-2 Rho-related GTP-binding protein RhoF isoform h2 (human), hRHOF/iso:h2

organism-modification


PR:000067392 Rho-related GTP-binding protein RhoF methylated 1 (human), hRHOF/Me:1

organism-modification


PR:000068254 Rho-related GTP-binding protein RhoF cysteinylated 1 (human), hRHOF/Cyst:1

organism-modification


PR:000078725 Rho-related GTP-binding protein RhoF methylated 2 (human), hRHOF/Me:2

gene


PR:000013981 Rho-related GTP-binding protein RhoG, RHOG

organism-gene


PR:P84095 Rho-related GTP-binding protein RhoG (human), hRHOG

organism-sequence


PR:P84095-1 Rho-related GTP-binding protein RhoG isoform 1 (human), hRHOG/iso:1

organism-modification


PR:000083835 Rho-related GTP-binding protein RhoG methylated 1 (human), hRHOG/Me:1

organism-gene


PR:P84096 Rho-related GTP-binding protein RhoG (mouse), mRHOG

organism-sequence


PR:P84096-1 Rho-related GTP-binding protein RhoG isoform 1 (mouse), mRHOG/iso:1

organism-gene


PR:Q7JWS8 AT17867p (fruit fly), fly-RHOG

sequence


PR:000040176 Rho-related GTP-binding protein RhoG isoform 1, RHOG/iso:1

organism-sequence


PR:P84095-1 Rho-related GTP-binding protein RhoG isoform 1 (human), hRHOG/iso:1

organism-sequence


PR:P84096-1 Rho-related GTP-binding protein RhoG isoform 1 (mouse), mRHOG/iso:1

gene


PR:000013982 Rho-related GTP-binding protein RhoH, RHOH

organism-gene


PR:Q15669 Rho-related GTP-binding protein RhoH (human), hRHOH

organism-sequence


PR:Q15669-1 Rho-related GTP-binding protein RhoH isoform 1 (human), hRHOH/iso:1

organism-modification


PR:000073769 Rho-related GTP-binding protein RhoH cysteinylated 1 (human), hRHOH/Cyst:1

organism-modification


PR:000081986 Rho-related GTP-binding protein RhoH methylated 1 (human), hRHOH/Me:1

organism-gene


PR:Q9D3G9 Rho-related GTP-binding protein RhoH (mouse), mRHOH

organism-sequence


PR:Q9D3G9-1 Rho-related GTP-binding protein RhoH isoform 1 (mouse), mRHOH/iso:1

sequence


PR:000040660 Rho-related GTP-binding protein RhoH isoform 1, RHOH/iso:1

organism-sequence


PR:Q15669-1 Rho-related GTP-binding protein RhoH isoform 1 (human), hRHOH/iso:1

organism-sequence


PR:Q9D3G9-1 Rho-related GTP-binding protein RhoH isoform 1 (mouse), mRHOH/iso:1

gene


PR:000013983 Rho-related GTP-binding protein RhoJ, RHOJ

organism-gene


PR:P34149 Rho-related protein racC (Dictyostelium discoideum), Dicty-RHOJ

organism-gene


PR:Q9ER71 Rho-related GTP-binding protein RhoJ (mouse), mRHOJ

organism-sequence


PR:Q9ER71-1 Rho-related GTP-binding protein RhoJ isoform 1 (mouse), mRHOJ/iso:1

organism-sequence


PR:Q9ER71-2 Rho-related GTP-binding protein RhoJ isoform m2 (mouse), mRHOJ/iso:m2

organism-gene


PR:Q9H4E5 Rho-related GTP-binding protein RhoJ (human), hRHOJ

organism-sequence


PR:Q9H4E5-1 Rho-related GTP-binding protein RhoJ isoform 1 (human), hRHOJ/iso:1

organism-sequence


PR:Q9H4E5-2 Rho-related GTP-binding protein RhoJ isoform h2 (human), hRHOJ/iso:h2

sequence


PR:000043283 Rho-related GTP-binding protein RhoJ isoform 1, RHOJ/iso:1

organism-sequence


PR:Q9ER71-1 Rho-related GTP-binding protein RhoJ isoform 1 (mouse), mRHOJ/iso:1

organism-sequence


PR:Q9H4E5-1 Rho-related GTP-binding protein RhoJ isoform 1 (human), hRHOJ/iso:1

gene


PR:000013984 Rho-related GTP-binding protein RhoQ, RHOQ

organism-gene


PR:P17081 Rho-related GTP-binding protein RhoQ (human), hRHOQ

organism-sequence


PR:P17081-1 Rho-related GTP-binding protein RhoQ isoform 1 (human), hRHOQ/iso:1

organism-gene


PR:Q8R527 Rho-related GTP-binding protein RhoQ (mouse), mRHOQ

organism-sequence


PR:Q8R527-1 Rho-related GTP-binding protein RhoQ isoform 1 (mouse), mRHOQ/iso:1

organism-gene


PR:Q9JJL4 Rho-related GTP-binding protein RhoQ (rat), rRHOQ

sequence


PR:000038969 Rho-related GTP-binding protein RhoQ isoform 1, RHOQ/iso:1

organism-sequence


PR:P17081-1 Rho-related GTP-binding protein RhoQ isoform 1 (human), hRHOQ/iso:1

organism-sequence


PR:Q8R527-1 Rho-related GTP-binding protein RhoQ isoform 1 (mouse), mRHOQ/iso:1

gene


PR:000013987 Rho-related GTP-binding protein RhoU, RHOU

organism-gene


PR:Q7L0Q8 Rho-related GTP-binding protein RhoU (human), hRHOU

organism-sequence


PR:Q7L0Q8-1 Rho-related GTP-binding protein RhoU isoform h1 (human), hRHOU/iso:h1

organism-sequence


PR:Q7L0Q8-2 Rho-related GTP-binding protein RhoU isoform h2 (human), hRHOU/iso:h2

organism-modification


PR:000045978 Rho-related GTP-binding protein RhoU phosphorylated 1 (human), hRHOU/Phos:1

organism-gene


PR:Q9EQT3 Rho-related GTP-binding protein RhoU (mouse), mRHOU

gene


PR:000013988 Rho-related GTP-binding protein RhoV, RHOV

organism-gene


PR:Q8VDU1 Rho-related GTP-binding protein RhoV (mouse), mRHOV

organism-sequence


PR:Q8VDU1-1 Rho-related GTP-binding protein RhoV isoform 1 (mouse), mRHOV/iso:1

organism-gene


PR:Q96L33 Rho-related GTP-binding protein RhoV (human), hRHOV

organism-sequence


PR:Q96L33-1 Rho-related GTP-binding protein RhoV isoform 1 (human), hRHOV/iso:1

organism-modification


PR:000079838 Rho-related GTP-binding protein RhoV cysteinylated 1 (human), hRHOV/Cyst:1

organism-gene


PR:Q9Z1Y0 Rho-related GTP-binding protein RhoV (rat), rRHOV

organism-sequence


PR:Q9Z1Y0-1 Rho-related GTP-binding protein RhoV isoform 1 (rat), rRHOV/iso:1

sequence


PR:000042592 Rho-related GTP-binding protein RhoV isoform 1, RHOV/iso:1

organism-sequence


PR:Q8VDU1-1 Rho-related GTP-binding protein RhoV isoform 1 (mouse), mRHOV/iso:1

organism-sequence


PR:Q96L33-1 Rho-related GTP-binding protein RhoV isoform 1 (human), hRHOV/iso:1

organism-sequence


PR:Q9Z1Y0-1 Rho-related GTP-binding protein RhoV isoform 1 (rat), rRHOV/iso:1

gene


PR:000014061 Rho-related GTP-binding protein Rho6, RND1

organism-gene


PR:Q8BLR7 Rho-related GTP-binding protein Rho6 (mouse), mRND1

organism-sequence


PR:Q8BLR7-1 Rho-related GTP-binding protein Rho6 isoform 1 (mouse), mRND1/iso:1

organism-sequence


PR:Q8BLR7-2 Rho-related GTP-binding protein Rho6 isoform m2 (mouse), mRND1/iso:m2

organism-sequence


PR:Q8BLR7-3 Rho-related GTP-binding protein Rho6 isoform m3 (mouse), mRND1/iso:m3

organism-gene


PR:Q92730 Rho-related GTP-binding protein Rho6 (human), hRND1

organism-sequence


PR:Q92730-1 Rho-related GTP-binding protein Rho6 isoform 1 (human), hRND1/iso:1

organism-modification


PR:000072849 Rho-related GTP-binding protein Rho6 methylated 1 (human), hRND1/Me:1

sequence


PR:000042330 Rho-related GTP-binding protein Rho6 isoform 1, RND1/iso:1

organism-sequence


PR:Q8BLR7-1 Rho-related GTP-binding protein Rho6 isoform 1 (mouse), mRND1/iso:1

organism-sequence


PR:Q92730-1 Rho-related GTP-binding protein Rho6 isoform 1 (human), hRND1/iso:1

gene


PR:000014062 Rho-related GTP-binding protein RhoN, RND2

organism-gene


PR:P52198 Rho-related GTP-binding protein RhoN (human), hRND2

organism-sequence


PR:P52198-1 Rho-related GTP-binding protein RhoN isoform 1 (human), hRND2/iso:1

organism-gene


PR:Q9QYM5 Rho-related GTP-binding protein RhoN (mouse), mRND2

organism-sequence


PR:Q9QYM5-1 Rho-related GTP-binding protein RhoN isoform 1 (mouse), mRND2/iso:1

sequence


PR:000039696 Rho-related GTP-binding protein RhoN isoform 1, RND2/iso:1

organism-sequence


PR:P52198-1 Rho-related GTP-binding protein RhoN isoform 1 (human), hRND2/iso:1

organism-sequence


PR:Q9QYM5-1 Rho-related GTP-binding protein RhoN isoform 1 (mouse), mRND2/iso:1

gene


PR:000014063 Rho-related GTP-binding protein RhoE, RND3

organism-gene


PR:P61587 Rho-related GTP-binding protein RhoE (human), hRND3

organism-sequence


PR:P61587-1 Rho-related GTP-binding protein RhoE isoform 1 (human), hRND3/iso:1

organism-gene


PR:P61588 Rho-related GTP-binding protein RhoE (mouse), mRND3

organism-sequence


PR:P61588-1 Rho-related GTP-binding protein RhoE isoform 1 (mouse), mRND3/iso:1

organism-gene


PR:Q6SA80 Rho-related GTP-binding protein RhoE (rat), rRND3

organism-sequence


PR:Q6SA80-1 Rho-related GTP-binding protein RhoE isoform 1 (rat), rRND3/iso:1

sequence


PR:000039948 Rho-related GTP-binding protein RhoE isoform 1, RND3/iso:1

organism-sequence


PR:P61587-1 Rho-related GTP-binding protein RhoE isoform 1 (human), hRND3/iso:1

organism-sequence


PR:P61588-1 Rho-related GTP-binding protein RhoE isoform 1 (mouse), mRND3/iso:1

organism-sequence


PR:Q6SA80-1 Rho-related GTP-binding protein RhoE isoform 1 (rat), rRND3/iso:1

organism-gene


PR:000050250 GTP-binding protein rho2 (Schizosaccharomyces pombe), Spom-rho2

organism-complex


PR:000050251 GTP-binding protein rho2, GTP-bound form (Schizosaccharomyces pombe), Spom-rho2/GTP+

organism-complex


PR:000059634 GTP-binding protein rho2, GDP-bound form (Schizosaccharomyces pombe), Spom-rho2/GDP+

organism-gene


PR:Q10133 GTP-binding protein rho2 (Schizosaccharomyces pombe 972h-), Spom972h-rho2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000122 fam:RHO

"A small GTPase with a short insert (approximately 13 residues) coincident with loop 8 of Ras. This insert region forms a highly charged helix without dramatic disturbance of the global structure shared with other small GTPases. Rho-related small GTPases act as key transducers of extracellular signals to regulate the actin cytoskeleton, cell cycle progression and gene expression." [PMID:11463812]		 acts_upstream_of_or_withinGO:0000902 cell morphogenesis PIRSF:PIRSF037169
GO:0007264 small GTPase mediated signal transduction PIRSF:PIRSF037169
GO:0007266 Rho protein signal transduction PIRSF:PIRSF037169
enablesGO:0003924 GTPase activity PIRSF:PIRSF037169
GO:0005515 protein binding PIRSF:PIRSF037169
GO:0005525 GTP binding PIRSF:PIRSF037169
PR:000036520 hRHOA/iso:1/IpCysEst:1
UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119 | PRO_0000030411, Cys-190, MOD:01119
"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 in human. UniProtKB:P61586-1, 1-190, Cys-190, MOD:01119." [PMID:1383236, PMID:16773203, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0030036 actin cytoskeleton organization PMID:16773203
GO:0043123 positive regulation of canonical NF-kappaB signal transduction PMID:12761501
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction PMID:12761501
located_inGO:0005886 plasma membrane PMID:16773203
PR:000036521 cow-RHOA/iso:1/IpCysEst:1
UniProtKB:P61585-1, 1-190, Cys-190, MOD:01119 | PRO_0000030407, Cys-190, MOD:01119
"A GTP-binding protein RhoA isoform 1 prenylated-cysteine methyl ester 1 in cow. UniProtKB:P61585-1, 1-190, Cys-190, MOD:01119." [PMID:1903193, PRO:CNA, PRO:DAN]		 located_inGO:0005886 plasma membrane PMID:1903193