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Protein Ontology report - secretin-like G-protein coupled receptor
PR:000001095 - http://purl.obolibrary.org/obo/PR_000001095
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001095   
  PRO namesecretin-like G-protein coupled receptor 
  Synonyms
PRO-Short-label: EXACT:fam:secretin
Other: EXACT:class B G-protein coupled receptor | subfamily B1 G-protein coupled receptor
  Definition"A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding." [PMID:15862553, PRO:WCB] 
  CommentClassification based on GRAFS system. [PMID:12761335]. 
  PRO Categoryfamily 
  ParentPR:000030035 G-protein coupled receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family5                                                  Organism-Family 0                                        
         Gene13                                                  Organism-Gene 41                                        
         Sequence12                                                  Organism-Sequence 56                                        
         Modification1                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001095 secretin-like G-protein coupled receptor, fam:secretin

family


PR:000044630 corticotropin-releasing factor receptor, fam:vgate_ion_chan

gene


PR:000005869 corticotropin-releasing factor receptor 1, CRHR1

organism-gene


PR:P34998 corticotropin-releasing factor receptor 1 (human), hCRHR1

organism-sequence


PR:P34998-1 corticotropin-releasing factor receptor 1 isoform hCRF-R1 (human), hCRHR1/iso:hCRF-R1

organism-sequence


PR:P34998-2 corticotropin-releasing factor receptor 1 isoform CRF-R2 (human), hCRHR1/iso:CRF-R2

organism-sequence


PR:P34998-3 corticotropin-releasing factor receptor 1 isoform hCRF-R3 (human), hCRHR1/iso:hCRF-R3

organism-sequence


PR:P34998-4 corticotropin-releasing factor receptor 1 isoform hCRF-R4 (human), hCRHR1/iso:hCRF-R4

organism-sequence


PR:P34998-5 corticotropin-releasing factor receptor 1 isoform h5 (human), hCRHR1/iso:h5

organism-modification


PR:000047066 corticotropin-releasing factor receptor 1, signal peptide removed form (human), hCRHR1/SigPep-

organism-gene


PR:P35347 corticotropin-releasing factor receptor 1 (mouse), mCRHR1

organism-sequence


PR:P35347-1 corticotropin-releasing factor receptor 1 isoform 1 (mouse), mCRHR1/iso:1

organism-gene


PR:P35353 corticotropin-releasing factor receptor 1 (rat), rCRHR1

organism-sequence


PR:P35353-1 corticotropin-releasing factor receptor 1 isoform 1 (rat), rCRHR1/iso:1

organism-gene


PR:Q90812 corticotropin-releasing factor receptor 1 (chicken), chick-CRHR1

sequence


PR:000039322 corticotropin-releasing factor receptor 1 isoform 2, CRHR1/iso:2

organism-sequence


PR:P34998-2 corticotropin-releasing factor receptor 1 isoform CRF-R2 (human), hCRHR1/iso:CRF-R2

organism-sequence


PR:P35347-1 corticotropin-releasing factor receptor 1 isoform 1 (mouse), mCRHR1/iso:1

organism-sequence


PR:P35353-1 corticotropin-releasing factor receptor 1 isoform 1 (rat), rCRHR1/iso:1

modification


PR:000019487 corticotropin-releasing factor receptor 1, signal peptide removed form, CRHR1/SigPep-

organism-modification


PR:000047066 corticotropin-releasing factor receptor 1, signal peptide removed form (human), hCRHR1/SigPep-

gene


PR:000005870 corticotropin-releasing factor receptor 2, CRHR2

organism-gene


PR:P47866 corticotropin-releasing factor receptor 2 (rat), rCRHR2

organism-sequence


PR:P47866-1 corticotropin-releasing factor receptor 2 isoform rCRF2-alpha (rat), rCRHR2/iso:rCRF2-alpha

organism-sequence


PR:P47866-2 corticotropin-releasing factor receptor 2 isoform rCRF2-beta (rat), rCRHR2/iso:rCRF2-beta

organism-gene


PR:Q13324 corticotropin-releasing factor receptor 2 (human), hCRHR2

organism-sequence


PR:Q13324-1 corticotropin-releasing factor receptor 2 isoform alpha (human), hCRHR2/iso:alpha

organism-sequence


PR:Q13324-2 corticotropin-releasing factor receptor 2 isoform beta (human), hCRHR2/iso:beta

organism-sequence


PR:Q13324-3 corticotropin-releasing factor receptor 2 isoform gamma (human), hCRHR2/iso:gamma

organism-sequence


PR:Q13324-4 corticotropin-releasing factor receptor 2 isoform D (human), hCRHR2/iso:D

organism-sequence


PR:Q13324-5 corticotropin-releasing factor receptor 2 isoform E (human), hCRHR2/iso:E

organism-sequence


PR:Q13324-6 corticotropin-releasing factor receptor 2 isoform F (human), hCRHR2/iso:F

organism-sequence


PR:Q13324-7 corticotropin-releasing factor receptor 2 isoform desQ (human), hCRHR2/iso:desQ

organism-gene


PR:Q60748 corticotropin-releasing factor receptor 2 (mouse), mCRHR2

organism-sequence


PR:C0K3M3 corticotropin-releasing factor receptor 2 isoform iv-beta (mouse), mCRHR2/iso:iv-beta
Yes
organism-sequence


PR:Q60748-1 corticotropin-releasing factor receptor 2 isoform mCRF2-alpha (mouse), mCRHR2/iso:mCRF2-alpha

organism-sequence


PR:Q60748-2 corticotropin-releasing factor receptor 2 isoform beta (mouse), mCRHR2/iso:beta
Yes
sequence


PR:000026079 corticotropin-releasing factor receptor 2 isoform alpha, CRHR2/iso:alpha

organism-sequence


PR:Q13324-1 corticotropin-releasing factor receptor 2 isoform alpha (human), hCRHR2/iso:alpha

sequence


PR:000026081 corticotropin-releasing factor receptor 2 isoform beta, CRHR2/iso:beta

organism-sequence


PR:Q13324-2 corticotropin-releasing factor receptor 2 isoform beta (human), hCRHR2/iso:beta

organism-sequence


PR:Q60748-2 corticotropin-releasing factor receptor 2 isoform beta (mouse), mCRHR2/iso:beta
Yes
sequence


PR:000026083 corticotropin-releasing factor receptor 2 isoform gamma, CRHR2/iso:gamma

organism-sequence


PR:Q13324-3 corticotropin-releasing factor receptor 2 isoform gamma (human), hCRHR2/iso:gamma

sequence


PR:000026086 corticotropin-releasing factor receptor 2 isoform iv-beta, CRHR2/iso:iv-beta

organism-sequence


PR:C0K3M3 corticotropin-releasing factor receptor 2 isoform iv-beta (mouse), mCRHR2/iso:iv-beta
Yes
family


PR:000049989 glucagon-like receptor, fam:CYP11B

gene


PR:000007892 glucagon receptor, GCGR

organism-gene


PR:P30082 glucagon receptor (rat), rGCGR

organism-sequence


PR:P30082-1 glucagon receptor isoform 1 (rat), rGCGR/iso:1

organism-gene


PR:P47871 glucagon receptor (human), hGCGR

organism-modification


PR:000047518 glucagon receptor, signal peptide removed form (human), hGCGR/SigPep-

organism-gene


PR:Q61606 glucagon receptor (mouse), mGCGR

organism-sequence


PR:Q61606-1 glucagon receptor isoform 1 (mouse), mGCGR/iso:1

sequence


PR:000041079 glucagon receptor isoform 1, GCGR/iso:1

organism-sequence


PR:P30082-1 glucagon receptor isoform 1 (rat), rGCGR/iso:1

organism-sequence


PR:Q61606-1 glucagon receptor isoform 1 (mouse), mGCGR/iso:1

gene


PR:000007972 growth hormone-releasing hormone receptor, GHRHR

organism-gene


PR:P32082 growth hormone-releasing hormone receptor (mouse), mGHRHR

organism-sequence


PR:P32082-1 growth hormone-releasing hormone receptor isoform 1 (mouse), mGHRHR/iso:1

organism-gene


PR:Q02643 growth hormone-releasing hormone receptor (human), hGHRHR

organism-sequence


PR:Q02643-1 growth hormone-releasing hormone receptor isoform 1 (human), hGHRHR/iso:1

organism-modification


PR:000047532 growth hormone-releasing hormone receptor, signal peptide removed form (human), hGHRHR/SigPep-

organism-gene


PR:Q02644 growth hormone-releasing hormone receptor (rat), rGHRHR

organism-sequence


PR:Q02644-1 growth hormone-releasing hormone receptor isoform Long (rat), rGHRHR/iso:Long

organism-sequence


PR:Q02644-2 growth hormone-releasing hormone receptor isoform Short (rat), rGHRHR/iso:Short

sequence


PR:000040249 growth hormone-releasing hormone receptor isoform 1, GHRHR/iso:1

organism-sequence


PR:P32082-1 growth hormone-releasing hormone receptor isoform 1 (mouse), mGHRHR/iso:1

organism-sequence


PR:Q02643-1 growth hormone-releasing hormone receptor isoform 1 (human), hGHRHR/iso:1

organism-sequence


PR:Q02644-2 growth hormone-releasing hormone receptor isoform Short (rat), rGHRHR/iso:Short

gene


PR:000007988 gastric inhibitory polypeptide receptor, GIPR

organism-gene


PR:P43219 gastric inhibitory polypeptide receptor (rat), rGIPR

organism-gene


PR:P48546 gastric inhibitory polypeptide receptor (human), hGIPR

organism-sequence


PR:P48546-1 gastric inhibitory polypeptide receptor isoform h1 (human), hGIPR/iso:h1

organism-sequence


PR:P48546-2 gastric inhibitory polypeptide receptor isoform h2 (human), hGIPR/iso:h2

organism-sequence


PR:P48546-3 gastric inhibitory polypeptide receptor isoform h3 (human), hGIPR/iso:h3

organism-modification


PR:000047535 gastric inhibitory polypeptide receptor, signal peptide removed form (human), hGIPR/SigPep-

organism-gene


PR:Q0P543 gastric inhibitory polypeptide receptor (mouse), mGIPR

organism-sequence


PR:Q0P543-1 gastric inhibitory polypeptide receptor isoform m1 (mouse), mGIPR/iso:m1

organism-sequence


PR:Q0P543-2 gastric inhibitory polypeptide receptor isoform m2 (mouse), mGIPR/iso:m2

gene


PR:000008040 glucagon-like peptide 1 receptor, GLP1R

organism-gene


PR:O35659 glucagon-like peptide 1 receptor (mouse), mGLP1R

organism-sequence


PR:O35659-1 glucagon-like peptide 1 receptor isoform 1 (mouse), mGLP1R/iso:1

organism-gene


PR:P30650 G-protein coupled receptor seb-2 (worm), GLP1R (worm)

organism-gene


PR:P32301 glucagon-like peptide 1 receptor (rat), rGLP1R

organism-gene


PR:P43220 glucagon-like peptide 1 receptor (human), hGLP1R

organism-sequence


PR:P43220-1 glucagon-like peptide 1 receptor isoform 1 (human), hGLP1R/iso:1

organism-modification


PR:000047553 glucagon-like peptide 1 receptor, signal peptide removed form (human), hGLP1R/SigPep-

sequence


PR:000039459 glucagon-like peptide 1 receptor isoform 1, GLP1R/iso:1

organism-sequence


PR:O35659-1 glucagon-like peptide 1 receptor isoform 1 (mouse), mGLP1R/iso:1

organism-sequence


PR:P43220-1 glucagon-like peptide 1 receptor isoform 1 (human), hGLP1R/iso:1

gene


PR:000008041 glucagon-like peptide 2 receptor, GLP2R

organism-gene


PR:O95838 glucagon-like peptide 2 receptor (human), hGLP2R

organism-gene


PR:Q5IXF8 glucagon-like peptide 2 receptor (mouse), mGLP2R

organism-gene


PR:Q9Z0W0 glucagon-like peptide 2 receptor (rat), rGLP2R

gene


PR:000014544 secretin receptor, SCTR

organism-gene


PR:P23811 secretin receptor (rat), rSCTR

organism-gene


PR:P47872 secretin receptor (human), hSCTR

organism-modification


PR:000049171 secretin receptor, signal peptide removed form (human), hSCTR/SigPep-

organism-gene


PR:Q5FWI2 secretin receptor (mouse), mSCTR

family


PR:000050016 parathyroid hormone receptor, fam:FLOT

gene


PR:000013430 parathyroid hormone/parathyroid hormone-related peptide receptor, PTH1R

organism-gene


PR:P25961 parathyroid hormone/parathyroid hormone-related peptide receptor (rat), rPTH1R

organism-sequence


PR:P25961-1 parathyroid hormone/parathyroid hormone-related peptide receptor isoform 1 (rat), rPTH1R/iso:1

organism-gene


PR:P41593 parathyroid hormone/parathyroid hormone-related peptide receptor (mouse), mPTH1R

organism-sequence


PR:P41593-1 parathyroid hormone/parathyroid hormone-related peptide receptor isoform 1 (mouse), mPTH1R/iso:1

organism-gene


PR:Q03431 parathyroid hormone/parathyroid hormone-related peptide receptor (human), hPTH1R

organism-modification


PR:000048947 parathyroid hormone/parathyroid hormone-related peptide receptor, signal peptide removed form (human), hPTH1R/SigPep-

sequence


PR:000039431 parathyroid hormone/parathyroid hormone-related peptide receptor isoform 1, PTH1R/iso:1

organism-sequence


PR:P25961-1 parathyroid hormone/parathyroid hormone-related peptide receptor isoform 1 (rat), rPTH1R/iso:1

organism-sequence


PR:P41593-1 parathyroid hormone/parathyroid hormone-related peptide receptor isoform 1 (mouse), mPTH1R/iso:1

gene


PR:000013432 parathyroid hormone 2 receptor, PTH2R

organism-gene


PR:P49190 parathyroid hormone 2 receptor (human), hPTH2R

organism-modification


PR:000048948 parathyroid hormone 2 receptor, signal peptide removed form (human), hPTH2R/SigPep-

organism-modification


PR:000076869 parathyroid hormone 2 receptor phosphorylated 1 (human), hPTH2R/Phos:1

organism-gene


PR:P70555 parathyroid hormone 2 receptor (rat), rPTH2R

organism-gene


PR:Q91V95 parathyroid hormone 2 receptor (mouse), mPTH2R

family


PR:000050033 VIP and PACAP receptor, hIg

gene


PR:000003762 pituitary adenylate cyclase-activating polypeptide type I receptor, ADCYAP1R1

organism-gene


PR:P32215 pituitary adenylate cyclase-activating polypeptide type I receptor (rat), rADCYAP1R1

organism-sequence


PR:P32215-1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform rHIP-HOP1 (rat), rADCYAP1R1/iso:rHIP-HOP1

organism-sequence


PR:P32215-2 pituitary adenylate cyclase-activating polypeptide type I receptor isoform rHOP1 (rat), rADCYAP1R1/iso:rHOP1

organism-sequence


PR:P32215-3 pituitary adenylate cyclase-activating polypeptide type I receptor isoform rHOP2 (rat), rADCYAP1R1/iso:rHOP2

organism-sequence


PR:P32215-4 pituitary adenylate cyclase-activating polypeptide type I receptor isoform HIP (rat), rADCYAP1R1/iso:HIP

organism-sequence


PR:P32215-5 pituitary adenylate cyclase-activating polypeptide type I receptor isoform PACAP-R (rat), rADCYAP1R1/iso:PACAP-R

organism-gene


PR:P41586 pituitary adenylate cyclase-activating polypeptide type I receptor (human), hADCYAP1R1

organism-sequence


PR:P41586-1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform N (human), hADCYAP1R1/iso:N

organism-sequence


PR:P41586-2 pituitary adenylate cyclase-activating polypeptide type I receptor isoform N-HOP1 (human), hADCYAP1R1/iso:N-HOP1

organism-sequence


PR:P41586-3 pituitary adenylate cyclase-activating polypeptide type I receptor isoform S (human), hADCYAP1R1/iso:S

organism-sequence


PR:P41586-4 pituitary adenylate cyclase-activating polypeptide type I receptor isoform hS-HOP1 (human), hADCYAP1R1/iso:hS-HOP1

organism-sequence


PR:P41586-5 pituitary adenylate cyclase-activating polypeptide type I receptor isoform VS (human), hADCYAP1R1/iso:VS

organism-modification


PR:000046268 pituitary adenylate cyclase-activating polypeptide type I receptor, signal peptide removed form (human), hADCYAP1R1/SigPep-

organism-gene


PR:P70205 pituitary adenylate cyclase-activating polypeptide type I receptor (mouse), mADCYAP1R1

organism-sequence


PR:P70205-1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 (mouse), mADCYAP1R1/iso:1

sequence


PR:000039429 pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2, ADCYAP1R1/iso:2

organism-sequence


PR:P41586-2 pituitary adenylate cyclase-activating polypeptide type I receptor isoform N-HOP1 (human), hADCYAP1R1/iso:N-HOP1

organism-sequence


PR:P70205-1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 (mouse), mADCYAP1R1/iso:1

gene


PR:000017300 vasoactive intestinal polypeptide receptor 1, VIPR1

organism-gene


PR:P30083 vasoactive intestinal polypeptide receptor 1 (rat), rVIPR1

organism-sequence


PR:P30083-1 vasoactive intestinal polypeptide receptor 1 isoform 1 (rat), rVIPR1/iso:1

organism-gene


PR:P32241 vasoactive intestinal polypeptide receptor 1 (human), hVIPR1

organism-sequence


PR:P32241-1 vasoactive intestinal polypeptide receptor 1 isoform Short (human), hVIPR1/iso:Short

organism-sequence


PR:P32241-2 vasoactive intestinal polypeptide receptor 1 isoform Long (human), hVIPR1/iso:Long

organism-sequence


PR:P32241-3 vasoactive intestinal polypeptide receptor 1 isoform h3 (human), hVIPR1/iso:h3

organism-sequence


PR:P32241-4 vasoactive intestinal polypeptide receptor 1 isoform h4 (human), hVIPR1/iso:h4

organism-sequence


PR:P32241-5 vasoactive intestinal polypeptide receptor 1 isoform h5 (human), hVIPR1/iso:h5

organism-modification


PR:000049658 vasoactive intestinal polypeptide receptor 1, signal peptide removed form (human), hVIPR1/SigPep-

organism-modification


PR:000082128 vasoactive intestinal polypeptide receptor 1 citrullinated 1 (human), hVIPR1/Cit:1

organism-gene


PR:P97751 vasoactive intestinal polypeptide receptor 1 (mouse), mVIPR1

organism-sequence


PR:P97751-1 vasoactive intestinal polypeptide receptor 1 isoform 1 (mouse), mVIPR1/iso:1

sequence


PR:000040191 vasoactive intestinal polypeptide receptor 1 isoform 1, VIPR1/iso:1

organism-sequence


PR:P30083-1 vasoactive intestinal polypeptide receptor 1 isoform 1 (rat), rVIPR1/iso:1

organism-sequence


PR:P97751-1 vasoactive intestinal polypeptide receptor 1 isoform 1 (mouse), mVIPR1/iso:1

gene


PR:000017301 vasoactive intestinal polypeptide receptor 2, VIPR2

organism-gene


PR:P35000 vasoactive intestinal polypeptide receptor 2 (rat), rVIPR2

organism-sequence


PR:P35000-1 vasoactive intestinal polypeptide receptor 2 isoform 1 (rat), rVIPR2/iso:1

organism-gene


PR:P41587 vasoactive intestinal polypeptide receptor 2 (human), hVIPR2

organism-sequence


PR:P41587-1 vasoactive intestinal polypeptide receptor 2 isoform h1 (human), hVIPR2/iso:h1

organism-sequence


PR:P41587-2 vasoactive intestinal polypeptide receptor 2 isoform h2 (human), hVIPR2/iso:h2

organism-modification


PR:000049659 vasoactive intestinal polypeptide receptor 2, signal peptide removed form (human), hVIPR2/SigPep-

organism-gene


PR:P41588 vasoactive intestinal polypeptide receptor 2 (mouse), mVIPR2

organism-sequence


PR:P41588-1 vasoactive intestinal polypeptide receptor 2 isoform 1 (mouse), mVIPR2/iso:1

sequence


PR:000039430 vasoactive intestinal polypeptide receptor 2 isoform 1, VIPR2/iso:1

organism-sequence


PR:P35000-1 vasoactive intestinal polypeptide receptor 2 isoform 1 (rat), rVIPR2/iso:1

organism-sequence


PR:P41588-1 vasoactive intestinal polypeptide receptor 2 isoform 1 (mouse), mVIPR2/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:C0K3M3 mCRHR2/iso:iv-beta

"A corticotropin-releasing factor receptor 2 isoform iv-beta that is encoded in the genome of mouse." [PMID:7708757, PRO:HJD]		 acts_upstream_of_or_withinGO:0043950 positive regulation of cAMP-mediated signaling MGI:3850921; PMID:19246489
GO:0043951 negative regulation of cAMP-mediated signaling MGI:3850921; PMID:19246489
located_inGO:0005783 endoplasmic reticulum MGI:3850921; PMID:19246489
GO:0005794 Golgi apparatus MGI:3850921; PMID:19246489
NOT GO:0009986 cell surface MGI:3850921; PMID:19246489
PR:Q60748-2 mCRHR2/iso:beta

"A corticotropin-releasing factor receptor 2 isoform beta that is encoded in the genome of mouse." [PMID:7708757, PRO:HJD]		 acts_upstream_of_or_withinGO:0043950 positive regulation of cAMP-mediated signaling PMID:19246489
located_inGO:0009986 cell surface MGI:3850921; PMID:19246489