back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - interferon regulatory factor 3-9
PR:000001863 - http://purl.obolibrary.org/obo/PR_000001863
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001863   
  PRO nameinterferon regulatory factor 3-9 
  Definition"An interferon regulatory factor with core architecture consisting of a single Interferon regulatory factor transcription factor domain (Pfam:PF00605) in the amino-terminal region, followed by an Interferon-regulatory factor 3 (Pfam:PF10401) domain." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000025304 interferon regulatory factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 16                                        
         Sequence7                                                  Organism-Sequence 28                                        
         Modification13                                                  Organism-Modification 40                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF005710
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001863 interferon regulatory factor 3-9, ICOS

gene


PR:000002045 interferon regulatory factor 3, IRF3

organism-gene


PR:P70671 interferon regulatory factor 3 (mouse), mIRF3

organism-sequence


PR:C0IXK2 interferon regulatory factor 3 isoform 2 (mouse), mIRF3/iso:2

organism-sequence


PR:P70671-1 interferon regulatory factor 3 isoform 1 (mouse), mIRF3/iso:1
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse), mIRF3/iso:1/Phos:1

Yes
organism-gene


PR:Q14653 interferon regulatory factor 3 (human), hIRF3

Yes
organism-sequence


PR:Q14653-1 interferon regulatory factor 3 isoform 1 (human), hIRF3/iso:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human), hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000045489 interferon regulatory factor 3 isoform 1 phosphorylated 2 (human), hIRF3/iso:1/Phos:2

Yes
organism-sequence


PR:Q14653-2 interferon regulatory factor 3 isoform h2 (human), hIRF3/iso:h2

organism-sequence


PR:Q14653-3 interferon regulatory factor 3 isoform h3 (human), hIRF3/iso:h3

organism-sequence


PR:Q14653-4 interferon regulatory factor 3 isoform h4 (human), hIRF3/iso:h4

organism-sequence


PR:Q14653-5 interferon regulatory factor 3 isoform h5 (human), hIRF3/iso:h5

organism-modification


PR:000028702 interferon regulatory factor 3 unmodified form (human), hIRF3/UnMod

Yes
organism-modification


PR:000045488 interferon regulatory factor 3 phosphorylated 1 (human), hIRF3/Phos:1

Yes
organism-modification


PR:000061027 interferon regulatory factor 3, initiator methionine removed form (human), hIRF3/InitMet-

organism-modification


PR:000065516 interferon regulatory factor 3 methylated 1 (human), hIRF3/Me:1

organism-modification


PR:000075605 interferon regulatory factor 3 cysteinylated 1 (human), hIRF3/Cyst:1

sequence


PR:000003257 interferon regulatory factor 3 isoform 1, IRF3/iso:1

organism-sequence


PR:P70671-1 interferon regulatory factor 3 isoform 1 (mouse), mIRF3/iso:1
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse), mIRF3/iso:1/Phos:1

Yes
organism-sequence


PR:Q14653-1 interferon regulatory factor 3 isoform 1 (human), hIRF3/iso:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human), hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000045489 interferon regulatory factor 3 isoform 1 phosphorylated 2 (human), hIRF3/iso:1/Phos:2

Yes
modification


PR:000003259 interferon regulatory factor 3 isoform 1 phosphorylated form, IRF3/iso:1/PhosRes+

modification


PR:000003260 interferon regulatory factor 3 isoform 1 phosphorylated 1, IRF3/iso:1/Phos:1

organism-modification


PR:000025763 interferon regulatory factor 3 isoform 1 phosphorylated 1 (human), hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse), mIRF3/iso:1/Phos:1

Yes
organism-modification


PR:000045489 interferon regulatory factor 3 isoform 1 phosphorylated 2 (human), hIRF3/iso:1/Phos:2

Yes
modification


PR:000028701 interferon regulatory factor 3 unmodified form, IRF3/UnMod

organism-modification


PR:000028702 interferon regulatory factor 3 unmodified form (human), hIRF3/UnMod

Yes
gene


PR:000002046 interferon regulatory factor 4, IRF4

organism-gene


PR:Q15306 interferon regulatory factor 4 (human), hIRF4

organism-sequence


PR:Q15306-1 interferon regulatory factor 4 isoform h1 (human), hIRF4/iso:h1

organism-sequence


PR:Q15306-2 interferon regulatory factor 4 isoform h2 (human), hIRF4/iso:h2

organism-modification


PR:000065544 interferon regulatory factor 4 methylated 1 (human), hIRF4/Me:1

organism-modification


PR:000070171 interferon regulatory factor 4 deaminated 1 (human), hIRF4/Deam:1

organism-modification


PR:000073206 interferon regulatory factor 4 methylated 2 (human), hIRF4/Me:2

organism-modification


PR:000075306 interferon regulatory factor 4 methylated 3 (human), hIRF4/Me:3

organism-modification


PR:000075783 interferon regulatory factor 4 cysteinylated 1 (human), hIRF4/Cyst:1

organism-modification


PR:000078479 interferon regulatory factor 4 cysteinylated 2 (human), hIRF4/Cyst:2

organism-modification


PR:000083983 interferon regulatory factor 4 cysteinylated 3 (human), hIRF4/Cyst:3

organism-modification


PR:000084232 interferon regulatory factor 4 deaminated 2 (human), hIRF4/Deam:2

organism-gene


PR:Q64287 interferon regulatory factor 4 (mouse), mIRF4

organism-sequence


PR:Q64287-1 interferon regulatory factor 4 isoform m1 (mouse), mIRF4/iso:m1

organism-sequence


PR:Q64287-2 interferon regulatory factor 4 isoform m2 (mouse), mIRF4/iso:m2

gene


PR:000002047 interferon regulatory factor 5, IRF5

organism-gene


PR:P56477 interferon regulatory factor 5 (mouse), mIRF5

organism-sequence


PR:B2CC69 interferon regulatory factor 5 isoform 2 (mouse), mIRF5/iso:2

organism-modification


PR:000027096 interferon regulatory factor 5 isoform 2 phosphorylated 1 (mouse), mIRF5/iso:2/Phos:1

Yes
organism-sequence


PR:P56477-1 interferon regulatory factor 5 isoform 1 (mouse), mIRF5/iso:1

organism-modification


PR:000027094 interferon regulatory factor 5 isoform 1 phosphorylated 1 (mouse), mIRF5/iso:1/Phos:1

Yes
organism-modification


PR:000027535 interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 (mouse), mIRF5/iso:1/K63polyUbiq:1

organism-gene


PR:Q13568 interferon regulatory factor 5 (human), hIRF5

organism-sequence


PR:Q13568-1 interferon regulatory factor 5 isoform 1 (human), hIRF5/iso:1

organism-sequence


PR:Q13568-2 interferon regulatory factor 5 isoform h2 (human), hIRF5/iso:h2

organism-sequence


PR:Q13568-3 interferon regulatory factor 5 isoform h3 (human), hIRF5/iso:h3

organism-sequence


PR:Q13568-4 interferon regulatory factor 5 isoform h4 (human), hIRF5/iso:h4

organism-sequence


PR:Q13568-5 interferon regulatory factor 5 isoform h5 (human), hIRF5/iso:h5

organism-sequence


PR:Q13568-6 interferon regulatory factor 5 isoform h6 (human), hIRF5/iso:h6

organism-modification


PR:000065832 interferon regulatory factor 5 methylated 1 (human), hIRF5/Me:1

organism-modification


PR:000065856 interferon regulatory factor 5 cysteinylated 1 (human), hIRF5/Cyst:1

organism-modification


PR:000071639 interferon regulatory factor 5 methylated 2 (human), hIRF5/Me:2

organism-modification


PR:000075034 interferon regulatory factor 5 methylated 3 (human), hIRF5/Me:3

organism-modification


PR:000079300 interferon regulatory factor 5 citrullinated 1 (human), hIRF5/Cit:1

organism-modification


PR:000081350 interferon regulatory factor 5 cysteinylated 2 (human), hIRF5/Cyst:2

organism-gene


PR:Q5ZJM5 uncharacterized protein, RCJMB04_17b14 translation product (chicken), chick-IRF5

sequence


PR:000027087 interferon regulatory factor 5 isoform 1, IRF5/iso:1

organism-sequence


PR:P56477-1 interferon regulatory factor 5 isoform 1 (mouse), mIRF5/iso:1

organism-modification


PR:000027094 interferon regulatory factor 5 isoform 1 phosphorylated 1 (mouse), mIRF5/iso:1/Phos:1

Yes
organism-modification


PR:000027535 interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 (mouse), mIRF5/iso:1/K63polyUbiq:1

organism-sequence


PR:Q13568-1 interferon regulatory factor 5 isoform 1 (human), hIRF5/iso:1

modification


PR:000027093 interferon regulatory factor 5 isoform 1 phosphorylated 1, IRF5/iso:1/Phos:1

organism-modification


PR:000027094 interferon regulatory factor 5 isoform 1 phosphorylated 1 (mouse), mIRF5/iso:1/Phos:1

Yes
modification


PR:000027534 interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1, IRF5/iso:1/Ubiq:1

organism-modification


PR:000027535 interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 (mouse), mIRF5/iso:1/K63polyUbiq:1

sequence


PR:000027090 interferon regulatory factor 5 isoform 2, IRF5/iso:2

organism-sequence


PR:B2CC69 interferon regulatory factor 5 isoform 2 (mouse), mIRF5/iso:2

organism-modification


PR:000027096 interferon regulatory factor 5 isoform 2 phosphorylated 1 (mouse), mIRF5/iso:2/Phos:1

Yes
modification


PR:000027095 interferon regulatory factor 5 isoform 2 phosphorylated 1, IRF5/iso:2/Phos:1

organism-modification


PR:000027096 interferon regulatory factor 5 isoform 2 phosphorylated 1 (mouse), mIRF5/iso:2/Phos:1

Yes
gene


PR:000002048 interferon regulatory factor 6, IRF6

organism-gene


PR:O14896 interferon regulatory factor 6 (human), hIRF6

organism-sequence


PR:O14896-1 interferon regulatory factor 6 isoform 1 (human), hIRF6/iso:1

organism-sequence


PR:O14896-2 interferon regulatory factor 6 isoform h2 (human), hIRF6/iso:h2

organism-gene


PR:P97431 interferon regulatory factor 6 (mouse), mIRF6

organism-sequence


PR:P97431-1 interferon regulatory factor 6 isoform 1 (mouse), mIRF6/iso:1

sequence


PR:000038013 interferon regulatory factor 6 isoform 1, IRF6/iso:1

organism-sequence


PR:O14896-1 interferon regulatory factor 6 isoform 1 (human), hIRF6/iso:1

organism-sequence


PR:P97431-1 interferon regulatory factor 6 isoform 1 (mouse), mIRF6/iso:1

gene


PR:000002049 interferon regulatory factor 7, IRF7

organism-gene


PR:P70434 interferon regulatory factor 7 (mouse), mIRF7

organism-gene


PR:Q92985 interferon regulatory factor 7 (human), hIRF7

organism-sequence


PR:Q92985-1 interferon regulatory factor 7 isoform A (human), hIRF7/iso:A

organism-modification


PR:000027082 interferon regulatory factor 7 isoform 1 phosphorylated 1 (human), hIRF7/iso:1/Phos:1

Yes
organism-modification


PR:000037791 interferon regulatory factor 7 isoform 1 unphosphorylated 1 (human), hIRF7/iso:1/UnPhos:1
Yes
organism-sequence


PR:Q92985-2 interferon regulatory factor 7 isoform B (human), hIRF7/iso:B

organism-sequence


PR:Q92985-3 interferon regulatory factor 7 isoform C (human), hIRF7/iso:C

organism-sequence


PR:Q92985-4 interferon regulatory factor 7 isoform D (human), hIRF7/iso:D

organism-modification


PR:000028704 interferon regulatory factor 7 unmodified form (human), hIRF7/UnMod

Yes
organism-modification


PR:000048049 interferon regulatory factor 7 phosphorylated 1 (human), hIRF7/Phos:1

organism-modification


PR:000048050 interferon regulatory factor 7 ubiquitinated form (human), hIRF7/UbiqLys+

organism-modification


PR:000066902 interferon regulatory factor 7 cysteinylated 1 (human), hIRF7/Cyst:1

organism-modification


PR:000078397 interferon regulatory factor 7 methylated 1 (human), hIRF7/Me:1

organism-modification


PR:000080104 interferon regulatory factor 7 cysteinylated 2 (human), hIRF7/Cyst:2

organism-modification


PR:000080211 interferon regulatory factor 7 methylated 2 (human), hIRF7/Me:2

sequence


PR:000003261 interferon regulatory factor 7 isoform 1, IRF7/iso:1

organism-sequence


PR:Q92985-1 interferon regulatory factor 7 isoform A (human), hIRF7/iso:A

organism-modification


PR:000027082 interferon regulatory factor 7 isoform 1 phosphorylated 1 (human), hIRF7/iso:1/Phos:1

Yes
organism-modification


PR:000037791 interferon regulatory factor 7 isoform 1 unphosphorylated 1 (human), hIRF7/iso:1/UnPhos:1
Yes
modification


PR:000003280 interferon regulatory factor 7 isoform 1 phosphorylated form, IRF7/iso:1/PhosRes+

modification


PR:000003281 interferon regulatory factor 7 isoform 1 phosphorylated 1, IRF7/iso:1/Phos:1

organism-modification


PR:000027082 interferon regulatory factor 7 isoform 1 phosphorylated 1 (human), hIRF7/iso:1/Phos:1

Yes
modification


PR:000037790 interferon regulatory factor 7 isoform 1 unphosphorylated 1, IRF7/iso:1/UnPhos:1

organism-modification


PR:000037791 interferon regulatory factor 7 isoform 1 unphosphorylated 1 (human), hIRF7/iso:1/UnPhos:1
Yes
modification


PR:000028703 interferon regulatory factor 7 unmodified form, IRF7/UnMod

organism-modification


PR:000028704 interferon regulatory factor 7 unmodified form (human), hIRF7/UnMod

Yes
gene


PR:000002050 interferon regulatory factor 8, IRF8

organism-gene


PR:P23611 interferon regulatory factor 8 (mouse), mIRF8

organism-sequence


PR:P23611-1 interferon regulatory factor 8 isoform 1 (mouse), mIRF8/iso:1

organism-modification


PR:000035707 interferon regulatory factor 8 isoform 1 sumoylated 1 (mouse), mIRF8/iso:1/Sumo:1
Yes
organism-modification


PR:000035709 interferon regulatory factor 8 isoform 1 unsumoylated form (mouse), mIRF8/iso:1/SumoRes-
Yes
organism-gene


PR:Q02556 interferon regulatory factor 8 (human), hIRF8

organism-modification


PR:000067923 interferon regulatory factor 8 methylated 1 (human), hIRF8/Me:1

organism-gene


PR:Q90871 interferon regulatory factor 8 (chicken), chick-IRF8

sequence


PR:000035704 interferon regulatory factor 8 isoform 1, IRF8/iso:1

organism-sequence


PR:P23611-1 interferon regulatory factor 8 isoform 1 (mouse), mIRF8/iso:1

organism-modification


PR:000035707 interferon regulatory factor 8 isoform 1 sumoylated 1 (mouse), mIRF8/iso:1/Sumo:1
Yes
organism-modification


PR:000035709 interferon regulatory factor 8 isoform 1 unsumoylated form (mouse), mIRF8/iso:1/SumoRes-
Yes
modification


PR:000035706 interferon regulatory factor 8 isoform 1 sumoylated 1, IRF8/iso:1/Sumo:1

organism-modification


PR:000035707 interferon regulatory factor 8 isoform 1 sumoylated 1 (mouse), mIRF8/iso:1/Sumo:1
Yes
modification


PR:000035708 interferon regulatory factor 8 isoform 1 unsumoylated form, IRF8/iso:1/SumoRes-

organism-modification


PR:000035709 interferon regulatory factor 8 isoform 1 unsumoylated form (mouse), mIRF8/iso:1/SumoRes-
Yes
gene


PR:000002051 interferon regulatory factor 9, IRF9

organism-gene


PR:Q00978 interferon regulatory factor 9 (human), hIRF9

organism-sequence


PR:Q00978-1 interferon regulatory factor 9 isoform 1 (human), hIRF9/iso:1

organism-modification


PR:000028650 interferon regulatory factor 9 isoform 1 acetylated 1 (human), hIRF9/iso:1/Ac:1

organism-modification


PR:000070535 interferon regulatory factor 9 methylated 1 (human), hIRF9/Me:1

organism-modification


PR:000080766 interferon regulatory factor 9 phosphorylated 1 (human), hIRF9/Phos:1

organism-gene


PR:Q61179 interferon regulatory factor 9 (mouse), mIRF9

sequence


PR:000028647 interferon regulatory factor 9 isoform 1, IRF9/iso:1

organism-sequence


PR:Q00978-1 interferon regulatory factor 9 isoform 1 (human), hIRF9/iso:1

organism-modification


PR:000028650 interferon regulatory factor 9 isoform 1 acetylated 1 (human), hIRF9/iso:1/Ac:1

modification


PR:000028649 interferon regulatory factor 9 isoform 1 acetylated 1, IRF9/iso:1/Ac:1

organism-modification


PR:000028650 interferon regulatory factor 9 isoform 1 acetylated 1 (human), hIRF9/iso:1/Ac:1

Back to top
ICOS forms found in complexes   

ICOS Component
 Complexes
PR:000025763 hIRF3/iso:1/Phos:1 PR:000036002 IRF3-P:IRF3-P:KPNA4 complex (human)
PR:000027082 hIRF7/iso:1/Phos:1 PR:000027084 IRF3-P:IRF7-P complex (human)
PR:000027086 IRF7-P:IRF7-P complex (human)
PR:000027094 mIRF5/iso:1/Phos:1 PR:000027536 IRF5-P:IRF5-P (mouse)
PR:000027096 mIRF5/iso:2/Phos:1 PR:000027537 IRF5BMv-P:IRF5BMv-P (mouse)
PR:000027097 mIRF3/iso:1/Phos:1 PR:000027098 IRF3-P:IRF3-P complex (mouse)
PR:000036043 IRF3-P:p65 complex (mouse)
PR:000036047 IRF3-P:p65:ISRE complex (mouse)
PR:000028702 hIRF3/UnMod PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028704 hIRF7/UnMod PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000045488 hIRF3/Phos:1 PR:000025765 IRF3-P:IRF3-P complex (human)
PR:000045489 hIRF3/iso:1/Phos:2 PR:000027084 IRF3-P:IRF7-P complex (human)
PR:Q14653 hIRF3 PR:000036045 IRF3:XPO1 complex (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025763 hIRF3/iso:1/Phos:1
UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046 | IRF3-P (human)
"An interferon regulatory factor 3 isoform 1 phosphorylated 1 in human. UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046." [PMID:10805757, PRO:CNA]		 enablesGO:0005515 protein binding with PR:O14980 chromosome region maintenance 1 protein homolog (human) PMID:10805757
located_inGO:0005829 cytosol Reactome:REACT_7149
PR:000035707 mIRF8/iso:1/Sumo:1
UniProtKB:P23611-1, Lys-310, MOD:01149 | SUMOylated IRF8
"An interferon regulatory factor 8 isoform 1 sumoylated 1 in mouse. UniProtKB:P23611-1, Lys-310, MOD:01149." [PMID:22942423, PRO:HJD]		 acts_upstream_of_or_withinNOT GO:0060261 positive regulation of transcription initiation by RNA polymerase II MGI:5448615; PMID:22942423
located_inGO:0005634 nucleus MGI:5448615; PMID:22942423
PR:000035709 mIRF8/iso:1/SumoRes-

"An interferon regulatory factor 8 isoform 1 unsumoylated form in mouse." [PMID:22942423, PRO:HJD]		 acts_upstream_of_or_withinGO:0060261 positive regulation of transcription initiation by RNA polymerase II MGI:5448615; PMID:22942423
located_inGO:0005634 nucleus MGI:5448615; PMID:22942423
PR:000037791 hIRF7/iso:1/UnPhos:1
UniProtKB:Q92985-1, Ser-477/Ser-479, PR:000026291 | IRF-7 unphosphorylated (human)
"An interferon regulatory factor 7 isoform 1 unphosphorylated 1 in human. UniProtKB:Q92985-1, Ser-477/Ser-479, PR:000026291." [PMID:10893229, PMID:14517278, PRO:CNA]		 located_inGO:0005737 cytoplasm Reactome:REACT_21735
PR:P70671-1 mIRF3/iso:1

"An interferon regulatory factor 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 located_inGO:0005737 cytoplasm MGI:3828224; PMID:18851954