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Protein Ontology report - CD14 molecule
PR:000001889 - http://purl.obolibrary.org/obo/PR_000001889
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001889   
  PRO nameCD14 molecule 
  Synonyms
PRO-Short-label: EXACT:CD14
Other: EXACT:monocyte differentiation antigen CD14 | myeloid cell-specific leucine-rich glycoprotein
  Definition"A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification7                                                  Organism-Modification 19                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002017
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001889 CD14 molecule
CD14

Yes
organism-gene


PR:B0BL87 CD14 molecule (chicken)
chick-CD14
Yes
Yes
organism-gene


PR:P08571 monocyte differentiation antigen CD14 (human)
hCD14
Yes
organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
Yes
organism-modification


PR:000036945 CD14 molecule cleaved and soluble form (human)
hCD14/ClvPrd/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble

organism-modification


PR:000037480 CD14 molecule cleaved 2 (human)
hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
Yes
Yes
organism-modification


PR:000050392 presepsin (human)
hPSEP

organism-modification


PR:000054476 monocyte differentiation antigen CD14 N-glycosylated 1 (human)
hCD14/NGlyco:1

organism-modification


PR:000054477 monocyte differentiation antigen CD14 O-glycosylated 1 (human)
hCD14/OGlyco:1

organism-modification


PR:000054478 monocyte differentiation antigen CD14 O-glycosylated 2 (human)
hCD14/OGlyco:2

organism-modification


PR:000054479 monocyte differentiation antigen CD14 O-glycosylated 3 (human)
hCD14/OGlyco:3

organism-modification


PR:000054480 monocyte differentiation antigen CD14 O-glycosylated 4 (human)
hCD14/OGlyco:4

organism-modification


PR:000054481 monocyte differentiation antigen CD14 O-glycosylated 5 (human)
hCD14/OGlyco:5

organism-modification


PR:000065690 monocyte differentiation antigen CD14 cysteinylated 1 (human)
hCD14/Cyst:1

organism-modification


PR:000079106 monocyte differentiation antigen CD14 deaminated 1 (human)
hCD14/Deam:1

organism-gene


PR:P10810 monocyte differentiation antigen CD14 (mouse)
mCD14
Yes
organism-modification


PR:000036850 CD14 molecule cleaved and soluble form (mouse)
mCD14/ClvPrd/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble

organism-modification


PR:000036946 CD14 molecule cleaved 2 (mouse)
mCD14/Clv:2

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble

organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)
mCD14/Clv:2/anchored

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble
Yes
organism-gene


PR:Q63691 monocyte differentiation antigen CD14 (rat)
rCD14

modification


PR:000018574 CD14 molecule, signal peptide removed form
CD14/SigPep-

modification


PR:000002146 CD14 molecule cleaved 1 soluble form
CD14/Clv:1/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
Yes
organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble
Yes
modification


PR:000002148 CD14 molecule cleaved and GPI-anchored form
CD14/ClvPrd/anchored

modification


PR:000036848 CD14 molecule cleaved 2
CD14/Clv:2
Yes
modification


PR:000002147 CD14 molecule cleaved 2 soluble form
CD14/Clv:2/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
Yes
Yes
modification


PR:000002149 CD14 molecule cleaved 2 GPI-anchored form
CD14/Clv:2/anchored

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)
mCD14/Clv:2/anchored

Yes
organism-modification


PR:000036946 CD14 molecule cleaved 2 (mouse)
mCD14/Clv:2

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble

organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)
mCD14/Clv:2/anchored

organism-modification


PR:000037480 CD14 molecule cleaved 2 (human)
hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
Yes
Yes
modification


PR:000036849 CD14 molecule cleaved and soluble form
CD14/ClvPrd/soluble

Yes
modification


PR:000002146 CD14 molecule cleaved 1 soluble form
CD14/Clv:1/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
Yes
organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble
Yes
modification


PR:000002147 CD14 molecule cleaved 2 soluble form
CD14/Clv:2/soluble

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
Yes
Yes
organism-modification


PR:000036850 CD14 molecule cleaved and soluble form (mouse)
mCD14/ClvPrd/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble

organism-modification


PR:000036945 CD14 molecule cleaved and soluble form (human)
hCD14/ClvPrd/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble

organism-modification


PR:000050392 presepsin (human)
hPSEP

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CD14 forms found in complexes   

CD14 Component
 Complexes
PR:000001889 CD14 PR:000037465 LPS:CD14 complex
PR:000002147 CD14/Clv:2/soluble PR:000025494 LPS:secreted CD14 alpha
PR:000025496 lipopolysaccharide receptor complex 2
PR:000025498 lipopolysaccharide receptor complex 4
PR:000002149 CD14/Clv:2/anchored PR:000025493 LPS:GPI-anchored CD14 complex
PR:000025495 lipopolysaccharide receptor complex 1
PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000036849 CD14/ClvPrd/soluble PR:000029989 LPS:secreted CD14 complex
PR:000036850 mCD14/ClvPrd/soluble PR:000037467 LPS:secreted CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:B0BL87 chick-CD14 PR:000037466 LPS:transmembrane CD14 complex (chicken)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702 hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703 hCD14/Clv:2/soluble acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271
PR:000036615 hCD14/Clv:1/soluble
UniProtKB:P08571, 20-367		 located_inGO:0005576 extracellular region PMID:7519994
PR:000036848 CD14/Clv:2
Example: UniProtKB:P08571, 20-345		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI:3836081; PMID:18854309
GO:0016020 membrane MGI:3836081; PMID:18854309
PR:000037469 mCD14/Clv:1/soluble
UniProtKB:P10810, 16-358		 located_inCL:0000129 microglial cell PMID:24659539
PR:B0BL87 chick-CD14 located_inGO:0005886 plasma membrane PMID:18761368
GO:0009986 cell surface PMID:18761368
PR:P08571 hCD14 located_inNOT CL:0000127 astrocyte PMID:24659539
PR:P10810 mCD14 located_inCL:0000127 astrocyte PMID:24659539