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Protein Ontology report - Ikaros-like zinc finger transcription factor
PR:000002986 - http://purl.obolibrary.org/obo/PR_000002986
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002986   
  PRO nameIkaros-like zinc finger transcription factor 
  Synonyms
Other: EXACT:Ikaros family of zinc finger transcription factors
  Definition"A protein that is the translation product of some gene evolved from the last common ancestor of human IKZF1 and human IKZF5 gene. The canonical protein sequence has a core domain architecture consisting of two copies of the Zinc finger, C2H2 type (Pfam:PF00096) domains, an N-terminal domain important for DNA recognition, and a C-terminal domain that mediates homo- and heterotypic associations between family members." [PMID:10978333, PMID:19342657] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 14                                        
         Sequence19                                                  Organism-Sequence 54                                        
         Modification2                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038846
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000002986 Ikaros-like zinc finger transcription factor, IKZF4

gene


PR:000001811 DNA-binding protein Ikaros, IKZF1

organism-gene


PR:O42410 DNA-binding protein Ikaros (chicken), chick-IKZF1

organism-sequence


PR:O42410-1 DNA-binding protein Ikaros isoform 1 (chicken), chick-IKZF1/iso:1

organism-gene


PR:Q03267 DNA-binding protein Ikaros (mouse), mIKZF1

organism-sequence


PR:Q03267-1 DNA-binding protein Ikaros isoform VI (mouse), mIKZF1/iso:VI
Yes
organism-sequence


PR:Q03267-2 DNA-binding protein Ikaros isoform I (mouse), mIKZF1/iso:I

organism-sequence


PR:Q03267-3 DNA-binding protein Ikaros isoform II (mouse), mIKZF1/iso:II

organism-sequence


PR:Q03267-4 DNA-binding protein Ikaros isoform III (mouse), mIKZF1/iso:III

organism-sequence


PR:Q03267-5 DNA-binding protein Ikaros isoform IV (mouse), mIKZF1/iso:IV

organism-sequence


PR:Q03267-6 DNA-binding protein Ikaros isoform V (mouse), mIKZF1/iso:V

organism-gene


PR:Q13422 DNA-binding protein Ikaros (human), hIKZF1

organism-sequence


PR:Q13422-1 DNA-binding protein Ikaros isoform Ik1 (human), hIKZF1/iso:Ik1

organism-sequence


PR:Q13422-2 DNA-binding protein Ikaros isoform Ik2 (human), hIKZF1/iso:Ik2

organism-sequence


PR:Q13422-3 DNA-binding protein Ikaros isoform hIk3 (human), hIKZF1/iso:hIk3

organism-sequence


PR:Q13422-4 DNA-binding protein Ikaros isoform hIk4 (human), hIKZF1/iso:hIk4

organism-sequence


PR:Q13422-5 DNA-binding protein Ikaros isoform Ik5 (human), hIKZF1/iso:Ik5

organism-sequence


PR:Q13422-6 DNA-binding protein Ikaros isoform Ik6 (human), hIKZF1/iso:Ik6

organism-sequence


PR:Q13422-7 DNA-binding protein Ikaros isoform hIk7 (human), hIKZF1/iso:hIk7

organism-sequence


PR:Q13422-8 DNA-binding protein Ikaros isoform Ikx (human), hIKZF1/iso:Ikx

organism-modification


PR:000069199 DNA-binding protein Ikaros methylated 1 (human), hIKZF1/Me:1

organism-modification


PR:000070058 DNA-binding protein Ikaros citrullinated 1 (human), hIKZF1/Cit:1

organism-modification


PR:000070450 DNA-binding protein Ikaros deaminated 1 (human), hIKZF1/Deam:1

sequence


PR:000002150 DNA-binding protein Ikaros isoform 1, IKZF1/iso:1

organism-sequence


PR:Q03267-1 DNA-binding protein Ikaros isoform VI (mouse), mIKZF1/iso:VI
Yes
organism-sequence


PR:Q13422-1 DNA-binding protein Ikaros isoform Ik1 (human), hIKZF1/iso:Ik1

modification


PR:000018259 DNA-binding protein Ikaros isoform 1 phosphorylated form, IKZF1/iso:1/PhosRes+

modification


PR:000018260 DNA-binding protein Ikaros isoform 1 phosphorylated 1, IKZF1/iso:1/Phos:1

sequence


PR:000002151 DNA-binding protein Ikaros isoform 2, IKZF1/iso:2

organism-sequence


PR:Q03267-2 DNA-binding protein Ikaros isoform I (mouse), mIKZF1/iso:I

organism-sequence


PR:Q13422-6 DNA-binding protein Ikaros isoform Ik6 (human), hIKZF1/iso:Ik6

sequence


PR:000002152 DNA-binding protein Ikaros isoform 3, IKZF1/iso:3

organism-sequence


PR:Q03267-3 DNA-binding protein Ikaros isoform II (mouse), mIKZF1/iso:II

sequence


PR:000002153 DNA-binding protein Ikaros isoform 4, IKZF1/iso:4

organism-sequence


PR:Q03267-4 DNA-binding protein Ikaros isoform III (mouse), mIKZF1/iso:III

organism-sequence


PR:Q13422-5 DNA-binding protein Ikaros isoform Ik5 (human), hIKZF1/iso:Ik5

sequence


PR:000002154 DNA-binding protein Ikaros isoform 5, IKZF1/iso:5

organism-sequence


PR:Q03267-5 DNA-binding protein Ikaros isoform IV (mouse), mIKZF1/iso:IV

sequence


PR:000002155 DNA-binding protein Ikaros isoform 6, IKZF1/iso:6

organism-sequence


PR:Q03267-6 DNA-binding protein Ikaros isoform V (mouse), mIKZF1/iso:V

organism-sequence


PR:Q13422-2 DNA-binding protein Ikaros isoform Ik2 (human), hIKZF1/iso:Ik2

gene


PR:000001976 zinc finger protein Aiolos, IKZF3

organism-gene


PR:O08900 zinc finger protein Aiolos (mouse), mIKZF3

organism-sequence


PR:O08900-1 zinc finger protein Aiolos isoform 1 (mouse), mIKZF3/iso:1

organism-gene


PR:Q9UKT9 zinc finger protein Aiolos (human), hIKZF3

organism-sequence


PR:Q9UKT9-1 zinc finger protein Aiolos isoform 1 (human), hIKZF3/iso:1

organism-sequence


PR:Q9UKT9-10 zinc finger protein Aiolos isoform h10 (human), hIKZF3/iso:h10

organism-sequence


PR:Q9UKT9-11 zinc finger protein Aiolos isoform h11 (human), hIKZF3/iso:h11

organism-sequence


PR:Q9UKT9-12 zinc finger protein Aiolos isoform h12 (human), hIKZF3/iso:h12

organism-sequence


PR:Q9UKT9-13 zinc finger protein Aiolos isoform h13 (human), hIKZF3/iso:h13

organism-sequence


PR:Q9UKT9-14 zinc finger protein Aiolos isoform h14 (human), hIKZF3/iso:h14

organism-sequence


PR:Q9UKT9-15 zinc finger protein Aiolos isoform h15 (human), hIKZF3/iso:h15

organism-sequence


PR:Q9UKT9-16 zinc finger protein Aiolos isoform h16 (human), hIKZF3/iso:h16

organism-sequence


PR:Q9UKT9-2 zinc finger protein Aiolos isoform 2 (human), hIKZF3/iso:2

organism-sequence


PR:Q9UKT9-3 zinc finger protein Aiolos isoform 3 (human), hIKZF3/iso:3

organism-sequence


PR:Q9UKT9-4 zinc finger protein Aiolos isoform 4 (human), hIKZF3/iso:4

organism-sequence


PR:Q9UKT9-5 zinc finger protein Aiolos isoform 5 (human), hIKZF3/iso:5

organism-sequence


PR:Q9UKT9-6 zinc finger protein Aiolos isoform 6 (human), hIKZF3/iso:6

organism-sequence


PR:Q9UKT9-7 zinc finger protein Aiolos isoform h7 (human), hIKZF3/iso:h7

organism-sequence


PR:Q9UKT9-8 zinc finger protein Aiolos isoform h8 (human), hIKZF3/iso:h8

organism-sequence


PR:Q9UKT9-9 zinc finger protein Aiolos isoform h9 (human), hIKZF3/iso:h9

organism-modification


PR:000073958 zinc finger protein Aiolos deaminated 1 (human), hIKZF3/Deam:1

organism-modification


PR:000080928 zinc finger protein Aiolos methylated 1 (human), hIKZF3/Me:1

sequence


PR:000002166 zinc finger protein Aiolos isoform 1, IKZF3/iso:1

organism-sequence


PR:O08900-1 zinc finger protein Aiolos isoform 1 (mouse), mIKZF3/iso:1

organism-sequence


PR:Q9UKT9-1 zinc finger protein Aiolos isoform 1 (human), hIKZF3/iso:1

sequence


PR:000002167 zinc finger protein Aiolos isoform 2, IKZF3/iso:2

organism-sequence


PR:Q9UKT9-2 zinc finger protein Aiolos isoform 2 (human), hIKZF3/iso:2

sequence


PR:000002168 zinc finger protein Aiolos isoform 3, IKZF3/iso:3

organism-sequence


PR:Q9UKT9-3 zinc finger protein Aiolos isoform 3 (human), hIKZF3/iso:3

sequence


PR:000002169 zinc finger protein Aiolos isoform 4, IKZF3/iso:4

organism-sequence


PR:Q9UKT9-4 zinc finger protein Aiolos isoform 4 (human), hIKZF3/iso:4

sequence


PR:000002170 zinc finger protein Aiolos isoform 5, IKZF3/iso:5

organism-sequence


PR:Q9UKT9-5 zinc finger protein Aiolos isoform 5 (human), hIKZF3/iso:5

sequence


PR:000002171 zinc finger protein Aiolos isoform 6, IKZF3/iso:6

organism-sequence


PR:Q9UKT9-6 zinc finger protein Aiolos isoform 6 (human), hIKZF3/iso:6

gene


PR:000002172 zinc finger protein Helios, IKZF2

organism-gene


PR:H2L008 zinc finger protein ztf-16 (worm), IKZF2 (worm)

organism-sequence


PR:H2L008-1 zinc finger protein ztf-16 isoform b (worm), IKZF2/iso:b (worm)

organism-sequence


PR:H2L008-2 zinc finger protein ztf-16 isoform a (worm), IKZF2/iso:a (worm)

organism-gene


PR:P81183 zinc finger protein Helios (mouse), mIKZF2
Yes
organism-sequence


PR:P81183-1 zinc finger protein Helios isoform B (mouse), mIKZF2/iso:B
Yes
organism-sequence


PR:P81183-2 zinc finger protein Helios isoform A (mouse), mIKZF2/iso:A
Yes
organism-gene


PR:Q9UKS7 zinc finger protein Helios (human), hIKZF2

organism-sequence


PR:Q9UKS7-1 zinc finger protein Helios isoform 1 (human), hIKZF2/iso:1

organism-sequence


PR:Q9UKS7-2 zinc finger protein Helios isoform 2 (human), hIKZF2/iso:2

organism-sequence


PR:Q9UKS7-3 zinc finger protein Helios isoform h3 (human), hIKZF2/iso:h3

organism-sequence


PR:Q9UKS7-4 zinc finger protein Helios isoform h4 (human), hIKZF2/iso:h4

organism-sequence


PR:Q9UKS7-5 zinc finger protein Helios isoform h5 (human), hIKZF2/iso:h5

organism-sequence


PR:Q9UKS7-6 zinc finger protein Helios isoform h6 (human), hIKZF2/iso:h6

organism-sequence


PR:Q9UKS7-7 zinc finger protein Helios isoform h7 (human), hIKZF2/iso:h7

organism-sequence


PR:Q9UKS7-8 zinc finger protein Helios isoform h8 (human), hIKZF2/iso:h8

organism-modification


PR:000081230 zinc finger protein Helios methylated 1 (human), hIKZF2/Me:1

organism-modification


PR:000081486 zinc finger protein Helios phosphorylated 1 (human), hIKZF2/Phos:1

sequence


PR:000002173 zinc finger protein Helios isoform 1, IKZF2/iso:1
Yes
organism-sequence


PR:P81183-1 zinc finger protein Helios isoform B (mouse), mIKZF2/iso:B
Yes
organism-sequence


PR:Q9UKS7-1 zinc finger protein Helios isoform 1 (human), hIKZF2/iso:1

sequence


PR:000002174 zinc finger protein Helios isoform 2, IKZF2/iso:2
Yes
organism-sequence


PR:P81183-2 zinc finger protein Helios isoform A (mouse), mIKZF2/iso:A
Yes
organism-sequence


PR:Q9UKS7-2 zinc finger protein Helios isoform 2 (human), hIKZF2/iso:2

gene


PR:000002984 zinc finger protein Eos, IKZF4

organism-gene


PR:Q8C208 zinc finger protein Eos (mouse), mIKZF4

organism-sequence


PR:Q8C208-1 zinc finger protein Eos isoform 1 (mouse), mIKZF4/iso:1
Yes
organism-sequence


PR:Q8C208-2 zinc finger protein Eos isoform 2 (mouse), mIKZF4/iso:2
Yes
organism-sequence


PR:Q8C208-3 zinc finger protein Eos isoform 3 (mouse), mIKZF4/iso:3

organism-sequence


PR:Q8C208-4 zinc finger protein Eos isoform 4 (mouse), mIKZF4/iso:4

organism-gene


PR:Q9H2S9 zinc finger protein Eos (human), hIKZF4

organism-sequence


PR:Q9H2S9-1 zinc finger protein Eos isoform 1 (human), hIKZF4/iso:1

organism-sequence


PR:Q9H2S9-2 zinc finger protein Eos isoform h2 (human), hIKZF4/iso:h2

organism-modification


PR:000069996 zinc finger protein Eos phosphorylated 1 (human), hIKZF4/Phos:1

organism-modification


PR:000079246 zinc finger protein Eos phosphorylated 2 (human), hIKZF4/Phos:2

sequence


PR:000002988 zinc finger protein Eos isoform 1, IKZF4/iso:1
Yes
organism-sequence


PR:Q8C208-1 zinc finger protein Eos isoform 1 (mouse), mIKZF4/iso:1
Yes
organism-sequence


PR:Q9H2S9-1 zinc finger protein Eos isoform 1 (human), hIKZF4/iso:1

sequence


PR:000002989 zinc finger protein Eos isoform 2, IKZF4/iso:2
Yes
organism-sequence


PR:Q8C208-2 zinc finger protein Eos isoform 2 (mouse), mIKZF4/iso:2
Yes
sequence


PR:000002990 zinc finger protein Eos isoform 3, IKZF4/iso:3

organism-sequence


PR:Q8C208-3 zinc finger protein Eos isoform 3 (mouse), mIKZF4/iso:3

sequence


PR:000002991 zinc finger protein Eos isoform 4, IKZF4/iso:4

organism-sequence


PR:Q8C208-4 zinc finger protein Eos isoform 4 (mouse), mIKZF4/iso:4

gene


PR:000002987 zinc finger protein Pegasus, IKZF5

organism-gene


PR:Q5ZLR2 zinc finger protein Pegasus (chicken), chick-IKZF5

organism-gene


PR:Q6DBW0 zinc finger protein Pegasus (zebrafish), z-IKZF5

organism-gene


PR:Q8BU00 zinc finger protein Pegasus (mouse), mIKZF5

organism-sequence


PR:Q8BU00-1 zinc finger protein Pegasus isoform 1 (mouse), mIKZF5/iso:1

organism-sequence


PR:Q8BU00-2 zinc finger protein Pegasus isoform m2 (mouse), mIKZF5/iso:m2

organism-sequence


PR:Q8BU00-3 zinc finger protein Pegasus isoform m3 (mouse), mIKZF5/iso:m3

organism-gene


PR:Q9H5V7 zinc finger protein Pegasus (human), hIKZF5

organism-sequence


PR:Q9H5V7-1 zinc finger protein Pegasus isoform 1 (human), hIKZF5/iso:1

organism-modification


PR:000065592 zinc finger protein Pegasus methylated 1 (human), hIKZF5/Me:1

sequence


PR:000043292 zinc finger protein Pegasus isoform 1, IKZF5/iso:1

organism-sequence


PR:Q8BU00-1 zinc finger protein Pegasus isoform 1 (mouse), mIKZF5/iso:1

organism-sequence


PR:Q9H5V7-1 zinc finger protein Pegasus isoform 1 (human), hIKZF5/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000002173 IKZF2/iso:1
zinc finger protein Helios isoform B
"A zinc finger protein Helios that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P81183-1 or a 1:1 ortholog thereof." [PRO:HJD]		 enablesGO:0046982 protein heterodimerization activity with PR:O08900|PR:Q03267-1 MGI:1203354; PMID:9560339
PR:000002174 IKZF2/iso:2
zinc finger protein Helios isoform A
"A zinc finger protein Helios that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P81183-2 or a 1:1 ortholog thereof." [PRO:HJD]		 enablesGO:0046982 protein heterodimerization activity with PR:P81183-1|PR:P81183-2 MGI:1203354; PMID:9560339
PR:000002988 IKZF4/iso:1

"A zinc finger protein Eos that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C208-1 or a 1:1 ortholog thereof." [PRO:HJD]		 enablesGO:0046982 protein heterodimerization activity with PR:Q03267-1 MGI:1333610; PMID:10218586
PR:000002989 IKZF4/iso:2

"A zinc finger protein Eos that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C208-2 or a 1:1 ortholog thereof." [PRO:HJD]		 enablesGO:0042803 protein homodimerization activity with PR:Q8C208-1 MGI:1333610; PMID:10218586
PR:P81183 mIKZF2
Helios | Ikzf2 | Zfpn1a2 | Znfn1a2 | Ikaros family zinc finger protein 2 (mouse)
"A zinc finger protein Helios that is encoded in the genome of mouse." [OMA:P81183, PRO:DNx]		 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II PMID:9560339
enablesGO:0042803 protein homodimerization activity with PR:P81183 Helios PMID:9560339
PR:P81183-1 mIKZF2/iso:B

"A zinc finger protein Helios isoform 1 that is encoded in the genome of mouse." [PRO:HJD]		 enablesGO:0046982 protein heterodimerization activity with PR:O08900 Ikaros family zinc finger protein 3 (mouse) MGI:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:O08900-1|PR:Q03267-1 MGI:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:Q03267-1 MGI:1203354; PMID:9560339
located_inGO:0005634 nucleus PMID:9560339
PR:P81183-2 mIKZF2/iso:A

"A zinc finger protein Helios isoform 2 that is encoded in the genome of mouse." [PRO:HJD]		 enablesGO:0046982 protein heterodimerization activity with PR:O08900-1|PR:Q03267-1 MGI:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:P81183-1 MGI:1203354; PMID:9560339
GO:0046982 protein heterodimerization activity with PR:P81183-2 MGI:1203354; PMID:9560339
located_inGO:0005634 nucleus PMID:9560339
PR:Q03267-1 mIKZF1/iso:VI

"A DNA-binding protein Ikaros isoform 1 that is encoded in the genome of mouse." [PRO:HJD]		 acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II PMID:12617992
GO:0001779 natural killer cell differentiation PMID:7923373
GO:0051138 positive regulation of NK T cell differentiation MGI:1340364; PMID:10366784
GO:0060041 retina development in camera-type eye MGI:3831471; PMID:18940586
enablesGO:0046982 protein heterodimerization activity with PR:P81183-1|PR:P81183-2 MGI:1333610; PMID:10218586
GO:0046982 protein heterodimerization activity with PR:Q8C208-1 MGI:1333610; PMID:10218586
located_inGO:0005634 nucleus MGI:2652944; PMID:12617992
PR:Q8C208-1 mIKZF4/iso:1

"A zinc finger protein Eos isoform 1 that is encoded in the genome of mouse." [PRO:HJD]		 enablesGO:0046982 protein heterodimerization activity with PR:Q03267-1 PMID:10218586
PR:Q8C208-2 mIKZF4/iso:2

"A zinc finger protein Eos isoform 2 that is encoded in the genome of mouse." [PRO:HJD]		 enablesGO:0042803 protein homodimerization activity with PR:Q8C208-1 PMID:10218586