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Protein Ontology report - conventional protein kinase C
PR:000003057 - http://purl.obolibrary.org/obo/PR_000003057
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003057   
  PRO nameconventional protein kinase C 
  Synonyms
Other: EXACT:cPKC | protein kinase C, alpha/beta/gamma types
RELATED:Calcium-dependent PKC
  Definition"A protein that is a member of the conventional phorbol ester (and diacylglycerol) receptor/protein kinase class. The canonical protein sequence has a core domain architecture consisting of two copies of the Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130), followed by a C2 domain (Pfam:PF00168), a Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433)." [PMID:1877391] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 13                                        
         Sequence4                                                  Organism-Sequence 17                                        
         Modification3                                                  Organism-Modification 20                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF0000550
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000003057 conventional protein kinase C, TMPRSS9/iso:3/Clv:1

gene


PR:000003058 protein kinase C alpha type, PRKCA

organism-gene


PR:P04409 protein kinase C alpha type (cow), cow-PRKCA

organism-gene


PR:P05130 protein kinase C, brain isozyme (fruit fly), fly-PRKCA

organism-sequence


PR:P05130-1 protein kinase C, brain isozyme isoform Long (fruit fly), fly-PRKCA/iso:Long

organism-sequence


PR:P05130-2 protein kinase C, brain isozyme isoform Short (fruit fly), fly-PRKCA/iso:Short

organism-gene


PR:P05696 protein kinase C alpha type (rat), rPRKCA

organism-sequence


PR:P05696-1 protein kinase C alpha type isoform 1 (rat), rPRKCA/iso:1

organism-gene


PR:P17252 protein kinase C alpha type (human), hPRKCA

organism-sequence


PR:P17252-1 protein kinase C alpha type isoform 1 (human), hPRKCA/iso:1

organism-modification


PR:000048910 protein kinase C alpha type, initiator methionine removed form (human), hPRKCA/InitMet-

organism-modification


PR:000048911 protein kinase C alpha type, initiator methionine removed phosphorylated 1 (human), hPRKCA/InitMet-/Phos:1

organism-modification


PR:000048912 protein kinase C alpha type, initiator methionine removed phosphorylated 2 (human), hPRKCA/InitMet-/Phos:2

organism-gene


PR:P20444 protein kinase C alpha type (mouse), mPRKCA

organism-modification


PR:000046148 protein kinase C alpha type phosphorylated 1 (mouse), mPRKCA/Phos:1

organism-gene


PR:P90980 protein kinase C-like 2 (worm), PRKCA (worm)

organism-sequence


PR:P90980-1 protein kinase C-like 2 isoform b (worm), PRKCA/iso:b (worm)

organism-sequence


PR:P90980-2 protein kinase C-like 2 isoform a (worm), PRKCA/iso:a (worm)

organism-sequence


PR:P90980-3 protein kinase C-like 2 isoform c (worm), PRKCA/iso:c (worm)

sequence


PR:000038974 protein kinase C alpha type isoform 1, PRKCA/iso:1

organism-sequence


PR:P05696-1 protein kinase C alpha type isoform 1 (rat), rPRKCA/iso:1

organism-sequence


PR:P17252-1 protein kinase C alpha type isoform 1 (human), hPRKCA/iso:1

modification


PR:000018782 protein kinase C alpha type, initiator methionine removed form, PRKCA/InitMet-

organism-modification


PR:000048910 protein kinase C alpha type, initiator methionine removed form (human), hPRKCA/InitMet-

organism-modification


PR:000048911 protein kinase C alpha type, initiator methionine removed phosphorylated 1 (human), hPRKCA/InitMet-/Phos:1

organism-modification


PR:000048912 protein kinase C alpha type, initiator methionine removed phosphorylated 2 (human), hPRKCA/InitMet-/Phos:2

gene


PR:000003059 protein kinase C beta type, PRKCB

organism-gene


PR:P05771 protein kinase C beta type (human), hPRKCB

organism-sequence


PR:P05771-1 protein kinase C beta type isoform Beta-I (human), hPRKCB/iso:Beta-I
Yes
organism-sequence


PR:P05771-2 protein kinase C beta type isoform Beta-II (human), hPRKCB/iso:Beta-II
Yes
organism-modification


PR:000049853 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification


PR:000049854 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1

organism-modification


PR:000049855 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification


PR:000049856 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2

organism-modification


PR:000048913 protein kinase C beta type, initiator methionine removed form (human), hPRKCB/InitMet-

organism-modification


PR:000048914 protein kinase C beta type, initiator methionine removed phosphorylated 1 (human), hPRKCB/InitMet-/Phos:1

organism-modification


PR:000048915 protein kinase C beta type, initiator methionine removed phosphorylated 2 (human), hPRKCB/InitMet-/Phos:2

organism-modification


PR:000049853 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification


PR:000049854 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1

organism-modification


PR:000049855 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification


PR:000049856 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2

organism-modification


PR:000049887 protein kinase C beta type phosphorylated 1 (human), hPRKCB/Phos:1

organism-gene


PR:P68403 protein kinase C beta type (rat), rPRKCB

organism-sequence


PR:P68403-1 protein kinase C beta type isoform Beta-I (rat), rPRKCB/iso:Beta-I

organism-sequence


PR:P68403-2 protein kinase C beta type isoform Beta-II (rat), rPRKCB/iso:Beta-II

organism-gene


PR:P68404 protein kinase C beta type (mouse), mPRKCB

organism-sequence


PR:P68404-1 protein kinase C beta type isoform Beta-I (mouse), mPRKCB/iso:Beta-I

organism-modification


PR:000049880 protein kinase C beta type isoform Beta-I phosphorylated 1 (mouse), mPRKCB/iso:Beta-I/Phos:1

organism-sequence


PR:P68404-2 protein kinase C beta type isoform Beta-II (mouse), mPRKCB/iso:Beta-II

organism-modification


PR:000049876 protein kinase C beta type isoform Beta-II phosphorylated 1 (mouse), mPRKCB/iso:Beta-II/Phos:1

organism-modification


PR:000049877 protein kinase C beta type isoform Beta-II phosphorylated 2 (mouse), mPRKCB/iso:Beta-II/Phos:2

organism-modification


PR:000049878 protein kinase C beta type isoform Beta-II phosphorylated 3 (mouse), mPRKCB/iso:Beta-II/Phos:3

organism-modification


PR:000049879 protein kinase C beta type isoform Beta-II phosphorylated 4 (mouse), mPRKCB/iso:Beta-II/Phos:4

organism-modification


PR:000049881 protein kinase C beta type phosphorylated 2 (mouse), mPRKCB/Phos:2

organism-modification


PR:000049882 protein kinase C beta type phosphorylated 1 (mouse), mPRKCB/Phos:1

organism-modification


PR:000049883 protein kinase C beta type phosphorylated 3 (mouse), mPRKCB/Phos:3

organism-gene


PR:Q7SY24 protein kinase C beta type (zebrafish), z-PRKCB

sequence


PR:000038682 protein kinase C beta type isoform 1, PRKCB/iso:1

organism-sequence


PR:P05771-1 protein kinase C beta type isoform Beta-I (human), hPRKCB/iso:Beta-I
Yes
organism-sequence


PR:P68404-1 protein kinase C beta type isoform Beta-I (mouse), mPRKCB/iso:Beta-I

organism-modification


PR:000049880 protein kinase C beta type isoform Beta-I phosphorylated 1 (mouse), mPRKCB/iso:Beta-I/Phos:1

sequence


PR:000038683 protein kinase C beta type isoform 2, PRKCB/iso:2

organism-sequence


PR:P05771-2 protein kinase C beta type isoform Beta-II (human), hPRKCB/iso:Beta-II
Yes
organism-modification


PR:000049853 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification


PR:000049854 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1

organism-modification


PR:000049855 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification


PR:000049856 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2

organism-sequence


PR:P68404-2 protein kinase C beta type isoform Beta-II (mouse), mPRKCB/iso:Beta-II

organism-modification


PR:000049876 protein kinase C beta type isoform Beta-II phosphorylated 1 (mouse), mPRKCB/iso:Beta-II/Phos:1

organism-modification


PR:000049877 protein kinase C beta type isoform Beta-II phosphorylated 2 (mouse), mPRKCB/iso:Beta-II/Phos:2

organism-modification


PR:000049878 protein kinase C beta type isoform Beta-II phosphorylated 3 (mouse), mPRKCB/iso:Beta-II/Phos:3

organism-modification


PR:000049879 protein kinase C beta type isoform Beta-II phosphorylated 4 (mouse), mPRKCB/iso:Beta-II/Phos:4

modification


PR:000018783 protein kinase C beta type, initiator methionine removed form, PRKCB/InitMet-

organism-modification


PR:000048913 protein kinase C beta type, initiator methionine removed form (human), hPRKCB/InitMet-

organism-modification


PR:000048914 protein kinase C beta type, initiator methionine removed phosphorylated 1 (human), hPRKCB/InitMet-/Phos:1

organism-modification


PR:000048915 protein kinase C beta type, initiator methionine removed phosphorylated 2 (human), hPRKCB/InitMet-/Phos:2

organism-modification


PR:000049853 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification


PR:000049854 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1

organism-modification


PR:000049855 protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification


PR:000049856 protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2

modification


PR:000049888 protein kinase C beta type phosphorylated 1, PRKCB/Phos:1

organism-modification


PR:000049882 protein kinase C beta type phosphorylated 1 (mouse), mPRKCB/Phos:1

organism-modification


PR:000049887 protein kinase C beta type phosphorylated 1 (human), hPRKCB/Phos:1

gene


PR:000003060 protein kinase C gamma type, PRKCG

organism-gene


PR:P05129 protein kinase C gamma type (human), hPRKCG

organism-sequence


PR:P05129-1 protein kinase C gamma type isoform 1 (human), hPRKCG/iso:1

organism-sequence


PR:P05129-2 protein kinase C gamma type isoform h2 (human), hPRKCG/iso:h2

organism-gene


PR:P63318 protein kinase C gamma type (mouse), mPRKCG

organism-sequence


PR:P63318-1 protein kinase C gamma type isoform 1 (mouse), mPRKCG/iso:1

organism-gene


PR:P63319 protein kinase C gamma type (rat), rPRKCG

organism-sequence


PR:P63319-1 protein kinase C gamma type isoform 1 (rat), rPRKCG/iso:1

sequence


PR:000038667 protein kinase C gamma type isoform 1, PRKCG/iso:1

organism-sequence


PR:P05129-1 protein kinase C gamma type isoform 1 (human), hPRKCG/iso:1

organism-sequence


PR:P63318-1 protein kinase C gamma type isoform 1 (mouse), mPRKCG/iso:1

organism-sequence


PR:P63319-1 protein kinase C gamma type isoform 1 (rat), rPRKCG/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1
UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047
"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]		 enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000049854 hPRKCB/iso:Beta-II/InitMet-/UnPhos:1 PMID:8749392
located_inGO:0005737 cytoplasm PMID:9756933
GO:0005886 plasma membrane PMID:9756933
PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]		 acts_upstream_of_or_withinincreased GO:0006468 protein phosphorylation relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392
enablesincreased GO:0001786 phosphatidylserine binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
increased GO:0005509 calcium ion binding relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
located_inincreased GO:0005737 cytoplasm relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933
PR:P05771-1 hPRKCB/iso:Beta-I
protein kinase C beta type isoform PRKCB1 (human)
"A protein kinase C beta type isoform 1 that is encoded in the genome of human." [PRO:DNx]		 acts_upstream_of_or_withinNOT GO:0001666 response to hypoxia MGI:3847400; PMID:18323529
located_inGO:0016020 membrane MGI:3847400; PMID:18323529
PR:P05771-2 hPRKCB/iso:Beta-II
protein kinase C beta type isoform PRKCB2 (human)
"A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]		 acts_upstream_of_or_withinGO:0001666 response to hypoxia MGI:3847400; PMID:18323529
located_inGO:0016020 membrane MGI:3847400; PMID:18323529