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Protein Ontology report - HSPH protein
PR:000003413 - http://purl.obolibrary.org/obo/PR_000003413
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003413   
  PRO nameHSPH protein 
  Synonyms
Other: EXACT:atypical Hsp70 protein | heat shock protein, Hsp105 type
  Definition"An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s." [PMID:16688212, PMID:18663603, PMID:7797574] 
  PRO Categoryfamily 
  ParentPR:000003425 Hsp70 family chaperone
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 14                                        
         Sequence3                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF006397
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000003413 HSPH protein, HSPH1/iso:1

gene


PR:000003410 heat shock protein 105 kDa, HSPH1

organism-gene


PR:A4UTN7 heat shock protein 105 kDa (pig), pig-HSPH1

organism-gene


PR:Q0IIM3 heat shock protein 105 kDa (cow), cow-HSPH1

organism-gene


PR:Q60446 heat shock protein 105 kDa (Chinese hamster), Cgri-HSPH1

organism-gene


PR:Q61699 heat shock protein 105 kDa (mouse), mHSPH1

organism-sequence


PR:Q61699-1 heat shock protein 105 kDa isoform HSP105-alpha (mouse), mHSPH1/iso:HSP105-alpha
Yes
organism-sequence


PR:Q61699-2 heat shock protein 105 kDa isoform HSP105-beta (mouse), mHSPH1/iso:HSP105-beta
Yes
organism-gene


PR:Q66HA8 heat shock protein 105 kDa (rat), rHSPH1

organism-gene


PR:Q92598 heat shock protein 105 kDa (human), hHSPH1

organism-sequence


PR:Q92598-1 heat shock protein 105 kDa isoform Alpha (human), hHSPH1/iso:Alpha

organism-sequence


PR:Q92598-2 heat shock protein 105 kDa isoform Beta (human), hHSPH1/iso:Beta

organism-sequence


PR:Q92598-3 heat shock protein 105 kDa isoform h3 (human), hHSPH1/iso:h3

organism-sequence


PR:Q92598-4 heat shock protein 105 kDa isoform h4 (human), hHSPH1/iso:h4

organism-modification


PR:000067382 heat shock protein 105 kDa deaminated 1 (human), hHSPH1/Deam:1

organism-modification


PR:000067413 heat shock protein 105 kDa deaminated 2 (human), hHSPH1/Deam:2

organism-modification


PR:000070017 heat shock protein 105 kDa methylated 1 (human), hHSPH1/Me:1

organism-modification


PR:000072334 heat shock protein 105 kDa methylated 2 (human), hHSPH1/Me:2

organism-modification


PR:000075309 heat shock protein 105 kDa cysteinylated 1 (human), hHSPH1/Cyst:1

organism-modification


PR:000077537 heat shock protein 105 kDa deaminated 3 (human), hHSPH1/Deam:3

organism-modification


PR:000085480 heat shock protein 105 kDa methylated 3 (human), hHSPH1/Me:3

sequence


PR:000003411 heat shock protein 105 kDa isoform 1, HSPH1/iso:1

organism-sequence


PR:Q92598-1 heat shock protein 105 kDa isoform Alpha (human), hHSPH1/iso:Alpha

sequence


PR:000003427 heat shock protein 105 kDa isoform 2, HSPH1/iso:2

organism-sequence


PR:Q92598-2 heat shock protein 105 kDa isoform Beta (human), hHSPH1/iso:Beta

gene


PR:000003414 heat shock 70 kDa protein 4, HSPA4

organism-gene


PR:O88600 heat shock 70 kDa protein 4 (rat), rHSPA4

organism-sequence


PR:O88600-1 heat shock 70 kDa protein 4 isoform 1 (rat), rHSPA4/iso:1

organism-gene


PR:P34932 heat shock 70 kDa protein 4 (human), hHSPA4

organism-sequence


PR:P34932-1 heat shock 70 kDa protein 4 isoform 1 (human), hHSPA4/iso:1

organism-sequence


PR:P34932-2 heat shock 70 kDa protein 4 isoform h2 (human), hHSPA4/iso:h2

organism-modification


PR:000065289 heat shock 70 kDa protein 4 methylated 1 (human), hHSPA4/Me:1

organism-modification


PR:000068334 heat shock 70 kDa protein 4 methylated 2 (human), hHSPA4/Me:2

organism-modification


PR:000072069 heat shock 70 kDa protein 4 cysteinylated 1 (human), hHSPA4/Cyst:1

organism-modification


PR:000072631 heat shock 70 kDa protein 4 cysteinylated 2 (human), hHSPA4/Cyst:2

organism-gene


PR:Q61316 heat shock 70 kDa protein 4 (mouse), mHSPA4

sequence


PR:000039317 heat shock 70 kDa protein 4 isoform 1, HSPA4/iso:1

organism-sequence


PR:O88600-1 heat shock 70 kDa protein 4 isoform 1 (rat), rHSPA4/iso:1

organism-sequence


PR:P34932-1 heat shock 70 kDa protein 4 isoform 1 (human), hHSPA4/iso:1

family


PR:000003415 heat shock protein SSE, HSPA4

gene


PR:000003416 heat shock protein homolog SSE1, SSE1

organism-gene


PR:P32589 heat shock protein homolog SSE1 (yeast), ySSE1

gene


PR:000003417 heat shock protein homolog SSE2, SSE2

organism-gene


PR:P32590 heat shock protein homolog SSE2 (yeast), ySSE2

gene


PR:000008809 heat shock 70 kDa protein 4L, HSPA4L

organism-gene


PR:O95757 heat shock 70 kDa protein 4L (human), hHSPA4L

organism-modification


PR:000078739 heat shock 70 kDa protein 4L cysteinylated 1 (human), hHSPA4L/Cyst:1

organism-modification


PR:000078775 heat shock 70 kDa protein 4L methylated 1 (human), hHSPA4L/Me:1

organism-modification


PR:000084766 heat shock 70 kDa protein 4L methylated 2 (human), hHSPA4L/Me:2

organism-gene


PR:P48722 heat shock 70 kDa protein 4L (mouse), mHSPA4L

organism-sequence


PR:P48722-1 heat shock 70 kDa protein 4L isoform m1 (mouse), mHSPA4L/iso:m1

organism-sequence


PR:P48722-2 heat shock 70 kDa protein 4L isoform m2 (mouse), mHSPA4L/iso:m2

organism-gene


PR:P83581 heat shock 70 kDa protein 4L (rat), rHSPA4L

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q61699-1 mHSPH1/iso:HSP105-alpha

"A heat shock protein 105 kDa (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61699-1." [PRO:DNx, UniProtKB:Q61699]		 acts_upstream_of_or_withinGO:1903748 negative regulation of establishment of protein localization to mitochondrion MGI:3688933; PMID:16857185
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide MGI:3822965; PMID:18681888
GO:1903753 negative regulation of p38MAPK cascade MGI:3822965; PMID:18681888
GO:2001234 negative regulation of apoptotic signaling pathway MGI:3688933; PMID:16857185
located_inGO:0005737 cytoplasm MGI:5607133; PMID:17643418
PR:Q61699-2 mHSPH1/iso:HSP105-beta

"A heat shock protein 105 kDa (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61699-2." [PRO:DNx, UniProtKB:Q61699]		 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II MGI:5607132; PMID:19028714
GO:0045944 positive regulation of transcription by RNA polymerase II MGI:5607132; PMID:19028714
GO:0045944 positive regulation of transcription by RNA polymerase II MGI:5607132; PMID:19028714
GO:0061098 positive regulation of protein tyrosine kinase activity MGI:4422145; PMID:19754877
GO:1903748 negative regulation of establishment of protein localization to mitochondrion MGI:3688933; PMID:16857185
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide MGI:3822965; PMID:18681888
GO:1903753 negative regulation of p38MAPK cascade MGI:3822965; PMID:18681888
GO:2001234 negative regulation of apoptotic signaling pathway MGI:3688933; PMID:16857185
located_inGO:0005634 nucleus MGI:5607133; PMID:17643418
GO:0005634 nucleus MGI:5607133; PMID:17643418
GO:0005634 nucleus MGI:5607133; PMID:17643418