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Protein Ontology report - smad2 isoform Long phosphorylated 2 (human)
PR:000025935 -
http://purl.obolibrary.org/obo/PR_000025935
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:000025935
PRO name
smad2 isoform Long phosphorylated 2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hSMAD2/iso:Long/Phos:2
PRO-proteoform-std
:
NARROW:
UniProtKB:Q15796-1
, Thr-8/Thr-220,
MOD:00047
|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467,
MOD:00046
Definition
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example:
UniProtKB:Q15796-1
, Thr-8/Thr-220,
MOD:00047
|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467,
MOD:00046
." [
PMID:12193595
]
Comment
Kinase=("MAPK3";
PR:000026189
; Thr-8/Thr-220/Ser-245/Ser-250/Ser-255). Kinase=("TGFBR1";
PR:000025963
; Ser-465/Ser-467).
PRO Category
organism-modification
Parent
PR:000000651
smad2 isoform Long phosphorylated 2
PR:Q15796
mothers against decapentaplegic homolog 2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Term Hierarchy
Visualization
DAG:
OLS:
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hSMAD2/iso:Long/Phos:2
forms found in complexes
hSMAD2/iso:Long/Phos:2
Component
Complexes
PR:000025935
hSMAD2/iso:Long/Phos:2
PR:000025946
smad2-smad4 protein complex 3 (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025935
hSMAD2/iso:Long/Phos:2
UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]
acts_upstream_of_or_within
GO:0006355
regulation of DNA-templated transcription
PMID:12193595
GO:0007165
signal transduction
PMID:12193595
GO:0060395
SMAD protein signal transduction
PMID:12193595
enables
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
PMID:12193595
GO:0003712
transcription coregulator activity
PMID:12193595
GO:0046332
SMAD binding
PMID:12193595
located_in
GO:0005634
nucleus
PMID:12193595
;
PMID:17074053