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Protein Ontology report - chymotrypsin-like elastase family member 2A, pro-form (mouse)
PR:000037244 -
http://purl.obolibrary.org/obo/PR_000037244
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000037244
PRO name
chymotrypsin-like elastase family member 2A, pro-form (mouse)
Synonyms
PRO-Short-label
:
EXACT:
mCELA2A/pro
PRO-proteoform-std
:
EXACT:
UniProtKB:P05208
, 17-271
Other
:
EXACT:
chymotrypsin-like elastase family member 2A, signal peptide removed form (mouse) | pro-Cela2a (mouse) | pro-Ela2 (mouse) | pro-elastase 2 (mouse)
Definition
"A chymotrypsin-like elastase family member 2A, signal peptide removed form in mouse.
UniProtKB:P05208
, 17-271." [
PMID:20179351
, PRO:KRC]
Comment
Note: Figure 3 (C) Western blot analysis of WT and Tg-ELA2 (Tg) epidermal and dermal extracts, using an anti-FLAG antibody, reveals exogenous ELA2flag as pro-forms and active forms in the epidermis of transgenic animals. Start site of pro-form (lacking signal peptide) is inferred by curator from UniProt record.
PRO Category
organism-modification
Parent
PR:000019775
chymotrypsin-like elastase family member 2A, signal peptide removed form
PR:P05208
chymotrypsin-like elastase family member 2A (mouse)
Taxon
NCBITaxon:10090
Mus musculus
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
0
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-modification
PR:000037244
chymotrypsin-like elastase family member 2A, pro-form (mouse)
mCELA2A/pro
organism-modification
PR:000037245
chymotrypsin-like elastase family member 2A, mature form (mouse)
mCELA2A/mature
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000037245
mCELA2A/mature
UniProtKB:P05208, 31-271 | PRO_0000027688 | Cela2a (mouse) | Ela2 (mouse) | elastase 2 (mouse)
"A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271." [PMID:20179351, PMID:3641189, PRO:KRC]
acts_upstream_of_or_within
GO:0006508
proteolysis
MGI:4440399
;
PMID:20179351
GO:0061436
establishment of skin barrier
MGI:4440399
;
PMID:20179351
enables
GO:0017171
serine hydrolase activity
MGI:4440399
;
PMID:20179351
GO:0017171
serine hydrolase activity
MGI:4440399
;
PMID:20179351
