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Protein Ontology report - TIR domain-containing adapter molecule 2
PR:000001750 - http://purl.obolibrary.org/obo/PR_000001750
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001750   
  PRO nameTIR domain-containing adapter molecule 2 
  Synonyms
PRO-Short-label: EXACT:TICAM2
Gene-based: RELATED:TIRAP3 | TIRP | TRAM
Other: EXACT:putative NF-kappa-B-activating protein 502 | TICAM-2 | Toll-like receptor adaptor protein 3 | Toll/interleukin-1 receptor domain-containing protein | TRIF-related adapter molecule
  Definition"A protein that is a translation product of the human TICAM2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037745
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001750 TIR domain-containing adapter molecule 2, TICAM2

organism-gene


PR:Q86XR7 TIR domain-containing adapter molecule 2 (human), hTICAM2

organism-sequence


PR:Q86XR7-1 TIR domain-containing adapter molecule 2 isoform 1 (human), hTICAM2/iso:1

organism-modification


PR:000027201 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human), hTICAM2/iso:1/InitMet-/Myr:1

organism-modification


PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human), hTICAM2/iso:1/InitMet-/MyrPhos:1

Yes
organism-sequence


PR:Q86XR7-2 TIR domain-containing adapter molecule 2 isoform h2 (human), hTICAM2/iso:h2

organism-modification


PR:000063665 TIR domain-containing adapter molecule 2, initiator methionine removed myristoylated and phosphorylated 1 (human), hTICAM2/InitMet-/MyrPhos:1

organism-gene


PR:Q8BJQ4 TIR domain-containing adapter molecule 2 (mouse), mTICAM2

Yes
organism-sequence


PR:Q8BJQ4-1 TIR domain-containing adapter molecule 2 isoform 1 (mouse), mTICAM2/iso:1

sequence


PR:000027197 TIR domain-containing adapter molecule 2 isoform 1, TICAM2/iso:1

organism-sequence


PR:Q86XR7-1 TIR domain-containing adapter molecule 2 isoform 1 (human), hTICAM2/iso:1

organism-modification


PR:000027201 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human), hTICAM2/iso:1/InitMet-/Myr:1

organism-modification


PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human), hTICAM2/iso:1/InitMet-/MyrPhos:1

Yes
organism-sequence


PR:Q8BJQ4-1 TIR domain-containing adapter molecule 2 isoform 1 (mouse), mTICAM2/iso:1

modification


PR:000027199 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed form, TICAM2/iso:1/InitMet-

modification


PR:000027200 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form, TICAM2/iso:1/InitMet-/MyrRes+

organism-modification


PR:000027201 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human), hTICAM2/iso:1/InitMet-/Myr:1

organism-modification


PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human), hTICAM2/iso:1/InitMet-/MyrPhos:1

Yes
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TICAM2 forms found in complexes   

TICAM2 Component
 Complexes
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028678 ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:Q8BJQ4 mTICAM2 PR:000027204 ticam2:activated TLR4 complex (mouse)
PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)