Protein Ontology Report - IkappaB kinase complex GO:0008385 - http://purl.obolibrary.org/obo/GO_0008385

Ontology Information
PRO ID	GO:0008385 Show OBO stanza
PRO name	IkappaB kinase complex
Synonyms	Other: EXACT: heterotrimeric IKK complex
Definition	A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203]
PRO Category
Parent	GO:0032991 protein-containing complex
Term Hierarchy Visualization	DAG     OLS     Cytoscape

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