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PRO no longer automatically creates terms corresponding to UniProtKB entries for the following organisms: Dictyostelium discoideum (slime mold; NCBITaxon:44689), Danio rerio (zebrafish; NCBITaxon:7955), Drosophila melanogaster (fruit fly; NCBITaxon:7227), and Caenorhabditis elegans (worm; NCBITaxon:6239). Please see these release notes for more information.

PRO provides an ontological representation of protein-related entities by explicitly defining them and showing the relationships between them. Each PRO term represents a distinct class of entities (including specific modified forms, orthologous isoforms, and protein complexes) ranging from the taxon-neutral to the taxon-specific (e.g. the entity representing all protein products of the human SMAD2 gene is described in PR:Q15796; one particular human SMAD2 protein form, phosphorylated on the last two serines of a conserved C-terminal SSxS motif is defined by PR:000025934).

Current release: 73.0; date: 2026-07-01; contains: 236541 active PRO terms.
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Example: methylated (sample output)
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Example: PR:000025934 (sample output)
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Example: smad (sample output)
Annotation: RACE-PRO PRO tracker
 PRO SPARQL

PRO encompasses three sub-ontologies: proteins based on evolutionary relatedness (ProEvo); protein forms produced from a given gene locus (ProForm); and protein-containing complexes (ProComp).
(Explanation of the figure)