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Protein Ontology Report - death-inducing signaling complex

GO:0031264 -
Ontology Information
PRO ID GO:0031264 Show OBO stanza
PRO name death-inducing signaling complex
Other: EXACT: death receptor-induced signaling complex
Definition A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]
Comment Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
PRO Category
Parent GO:0032991 protein-containing complex
Term Hierarchy Visualization DAG     OLS     Cytoscape