| PRO ID |
GO:0031264
Show OBO stanza
|
| PRO name |
death-inducing signaling complex |
| Synonyms |
| Other: |
EXACT: |
death receptor-induced signaling complex |
|
| Definition |
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
[GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]
|
| Comment |
Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. |
| PRO Category |
|
| Parent |
GO:0032991 protein-containing complex |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
|
