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Protein Ontology Report - interferon regulatory factor complex

GO:0097071 -
Ontology Information
PRO ID GO:0097071 Show OBO stanza
PRO name interferon regulatory factor complex
Other: EXACT: IRF complex
Definition A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. [GOC:cna, PMID:20043992]
PRO Category
Parent GO:0032991 protein-containing complex
Term Hierarchy Visualization DAG     OLS     Cytoscape