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Protein Ontology Report - GAIT complex

GO:0097452 -
Ontology Information
PRO ID GO:0097452 Show OBO stanza
PRO name GAIT complex
Other: EXACT: gamma interferon-activated inhibitor of translation complex
Definition A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. [GOC:br, PMID:15479637, PMID:23071094]
PRO Category
Parent GO:0032991 protein-containing complex
Term Hierarchy Visualization DAG     OLS     Cytoscape