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Protein Ontology Report - platelet-derived growth factor complex

GO:1990265 -
Ontology Information
PRO ID GO:1990265 Show OBO stanza
PRO name platelet-derived growth factor complex
Other: RELATED: PDGF complex
Definition A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). [GOC:bhm, PMID:11331882]
Comment An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay).
PRO Category
Parent GO:0032991 protein-containing complex
Term Hierarchy Visualization DAG     OLS     Cytoscape