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Protein Ontology Report - SLC9A3R1

PR:000001041 -
Ontology Information
PRO ID PR:000001041 Show OBO stanza / PAF
PRO name Na(+)/H(+) exchange regulatory cofactor NHE-RF1
PRO-short-label: SLC9A3R1
EXACT: EBP50; NHERF-1; ezrin-radixin-moesin-binding phosphoprotein 50; regulatory cofactor of Na(+)/H(+) exchanger; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 isoform A3 regulatory factor 1
Gene-based: NHERF; NHERF1
Definition A Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain that is a translation product of the human SLC9A3R1 gene or a 1:1 ortholog thereof. It contains two copies of the PDZ domain at the N terminus and an EBP50 domain at the C-terminus. The latter allows interaction with FERM domains, resulting in the activation of ERM proteins (PR:000001030), with subsequent cytoskeletal modulation and cellular growth control. [PRO:CNA]
PRO Category gene
Parent PR:000001043 Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 2 organism-sequence 5
modification 2 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
capable_of GO:0051219 phosphoprotein binding with PR:000044790 mEZR/iso:1/Phos:5 PMID:15591354
located_in GO:0031526 brush border membrane PMID:15591354
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0031526 brush border membrane PR:P70441-1 mSLC9A3R1/iso:1