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Protein Ontology Report - hBCL2

PR:P10415 - http://purl.obolibrary.org/obo/PR_P10415
This page represents a class of proteins encompassing all the protein products of the BCL2 gene in human.
Ontology Information
PRO ID PR:P10415 Show OBO stanza / PAF
PRO name apoptosis regulator Bcl-2 (human)
Synonyms
PRO-short-label: hBCL2
Gene-based: BCL2
Definition An apoptosis regulator Bcl-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P10415]
PRO Category organism-gene
Parent PR:000002307 apoptosis regulator Bcl-2
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 4
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027461
hBCL2/iso:1/Phos:2
Thr-74, MOD:00047
participates_in GO:0043066 negative regulation of apoptotic process PMID:12039864
PR:000027463
hBCL2/iso:1/Phos:3
Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046
capable_of NOT GO:0005515 protein binding with PR:Q14457 hBECN1 PMID:18570871, PMID:19029119
participates_in GO:0016239 positive regulation of macroautophagy PMID:18570871, PMID:19029119
PR:000027465
hBCL2/iso:1/Phos:4
Thr-69, MOD:00047|Ser-87, MOD:00046
participates_in GO:0043065 positive regulation of apoptotic process PMID:15703383
PR:000027467
hBCL2/iso:1/Phos:5
Thr-56, MOD:00047
participates_in GO:0045839 negative regulation of mitotic nuclear division PMID:10766756
PR:P10415-1
hBCL2/iso:Alpha
capable_of GO:0005515 protein binding with PR:Q07813 mBAX PMID:9109491
capable_of GO:0005515 protein binding with PR:P63328 mPPP3CA PMID:9109491
located_in GO:0005886 plasma membrane PMID:9109491
participates_in GO:0070885 negative regulation of calcineurin-NFAT signaling cascade PMID:9109491
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000027461 hBCL2/iso:1/Phos:2
Thr-74, MOD:00047
PMID:12039864
GO:0016239 positive regulation of macroautophagy PR:000027463 hBCL2/iso:1/Phos:3
Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046
PMID:18570871, PMID:19029119
GO:0045839 negative regulation of mitotic nuclear division PR:000027467 hBCL2/iso:1/Phos:5
Thr-56, MOD:00047
PMID:10766756
GO:0043065 positive regulation of apoptotic process PR:000027465 hBCL2/iso:1/Phos:4
Thr-69, MOD:00047|Ser-87, MOD:00046
PMID:15703383
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade PR:P10415-1 hBCL2/iso:Alpha

PMID:9109491
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:P10415-1 hBCL2/iso:Alpha

PMID:9109491

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