Protein Ontology Report - TGF-beta-like cystine-knot cytokine PR:000000008 - http://purl.obolibrary.org/obo/PR_000000008

Ontology Information
PRO ID	PR:000000008 Show OBO stanza
PRO name	TGF-beta-like cystine-knot cytokine
Synonyms	Other: RELATED: TGF-beta superfamily
Definition	A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain. [PRO:CNA]
PRO Category	family
Parent	PR:000000001 protein
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	PIRSF:PIRSF800009

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