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Protein Ontology Report - TGF-beta

PR:000000046 - http://purl.obolibrary.org/obo/PR_000000046
Ontology Information
PRO ID PR:000000046 Show OBO stanza / PAF
PRO name TGF-beta
Synonyms
Other: EXACT: transforming growth factor beta
Definition A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation. [PIRSF:PIRSF001787]
PRO Category family
Parent PR:000000008 TGF-beta-like cystine-knot cytokine
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000046
TGF-beta
acts_upstream_of_or_within GO:0042127 regulation of cell population proliferation PIRSF:PIRSF001787
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF001787
enables GO:0008083 growth factor activity PIRSF:PIRSF001787
enables GO:0005160 transforming growth factor beta receptor binding PIRSF:PIRSF001787
enables GO:0042803 protein homodimerization activity PIRSF:PIRSF001787

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