PRO Entry Report - PR:000000403

Protein Ontology Report - hTGFB1/var:C225R

PR:000000403 - http://purl.obolibrary.org/obo/PR_000000403

Protein Forms Annotations

Ontology Information

PRO ID

PR:000000403 Show OBO stanza / PAF / GPI

PRO name

TGF-beta 1 sequence variant C225R (human)

Synonyms

PRO-short-label:	EXACT:	hTGFB1/var:C225R
PRO-proteoform-std:	EXACT:	UniProtKB:P01137, Cys-225, CHEBI:29952
Other:	EXACT:	TGF-beta 1 sequence variant 6 (human)

Definition

A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-225, CHEBI:29952. [PMID:12493741, PRO:CNA, PRO:DAN]

PRO Category

organism-sequence

Parent

PR:P01137 transforming growth factor beta-1 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	UniProtKB_VAR:VAR_017611

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000403 hTGFB1/var:C225R Cys-225, CHEBI:29952	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:11062463, PMID:12493741, PMID:12843182
	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11062463, PMID:12493741, PMID:12843182
	associated_with_disease_progression	DOID:4997 Camurati-Engelmann disease	PMID:12493741
	enables	GO:0008083 growth factor activity increased relative to PR:000002555 TGFB1/iso:1/UnMod	PMID:11062463, PMID:12493741, PMID:12843182
	located_in	GO:0005615 extracellular space	PMID:11062463, PMID:12493741, PMID:12843182

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005615 extracellular space	PR:000000403 hTGFB1/var:C225R Cys-225, CHEBI:29952	PMID:11062463, PMID:12493741, PMID:12843182

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