| PRO ID |
PR:000001006
Show OBO stanza
/ PAF
|
| PRO name |
receptor-type tyrosine-protein phosphatase C |
| Synonyms |
| PRO-short-label: |
EXACT: |
PTPRC |
| Gene-based: |
RELATED: |
CD45 |
| Other: |
EXACT: |
L-CA | leukocyte common antigen | ly-5 | lymphocyte antigen 5 |
|
BROAD: |
T200 |
|
| Definition |
A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.
[PMID:1351092, PRO:CNA]
|
| Comment |
Requested by=CL. |
| PRO Category |
gene |
| Parent |
PR:000000001 protein |
| Terms by PRO Category |
Retrieve All terms OBO Stanza
/ PAF
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms |
|
gene
|
1 |
organism-gene
|
4 |
|
sequence
|
8 |
organism-sequence
|
22 |
|
modification
|
17 |
organism-modification
|
4 |
|
union
|
0 |
|
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