PRO Entry Report - PR:000001719

Protein Ontology Report - TRPM8

PR:000001719 - http://purl.obolibrary.org/obo/PR_000001719

Protein Forms Annotations

Ontology Information

PRO ID

PR:000001719 Show OBO stanza / PAF

PRO name

transient receptor potential cation channel TRPM8

Synonyms

PRO-short-label:	EXACT:	TRPM8
Gene-based:	RELATED:	LTRPC6 \| TRPP8
Other:	EXACT:	LTrpC-6 \| LTrpC6 \| Trp-p8 \| long transient receptor potential channel 6 \| transient receptor potential p8

Definition

A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2). [PMID:15852009, PRO:CNA]

PRO Category

gene

Parent

PR:000044657 transient receptor potential channel protein

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	3
sequence	3	organism-sequence	5
modification	2	organism-modification	1
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	IUPHARobj:500, PIRSF:PIRSF038526

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:Q8R4D5 mTRPM8	acts_upstream_of_or_within	GO:0009409 response to cold	PMID:17015441
	acts_upstream_of_or_within	GO:0070207 protein homotrimerization	PMID:17015441
	acts_upstream_of_or_within	GO:0050955 thermoception	PMID:17481392
	acts_upstream_of_or_within	GO:0050955 thermoception	PMID:17538622
	acts_upstream_of_or_within	GO:0051289 protein homotetramerization	PMID:17015441
	acts_upstream_of_or_within	GO:0009409 response to cold	PMID:17481391
	acts_upstream_of_or_within	GO:0009409 response to cold	PMID:17481392
	acts_upstream_of_or_within	GO:0009409 response to cold	PMID:17538622
	acts_upstream_of_or_within	GO:0006816 calcium ion transport	PMID:17015441
	acts_upstream_of_or_within	GO:0050955 thermoception	PMID:17481391
	enables	GO:0005262 calcium channel activity	PMID:17015441
	enables	GO:0005262 calcium channel activity	PMID:17538622
	enables	GO:0042803 protein homodimerization activity with PR:Q8R4D5 mTRPM8	PMID:17015441
	located_in	GO:0009897 external side of plasma membrane	PMID:17015441

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0009897 external side of plasma membrane	PR:Q8R4D5 mTRPM8	PMID:17015441

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