Protein Ontology Report - IRAK4 PR:000001780 - http://purl.obolibrary.org/obo/PR_000001780

Ontology Information
PRO ID	PR:000001780 Show OBO stanza / PAF
PRO name	interleukin-1 receptor-associated kinase 4
Synonyms	PRO-short-label: EXACT: IRAK4 Other: EXACT: IRAK-4 | renal carcinoma antigen NY-REN-64
Definition	A protein that is a translation product of the human IRAK4 gene or a 1:1 ortholog thereof. The archetypical form consists of an N-terminal Death domain (Pfam:PF00531) and a C-terminal Protein kinase domain (Pfam:PF00069). This protein is an essential component of innate immunity. [PMID:11960013, PMID:16177054, PRO:CNA]
PRO Category	gene
Parent	PR:000000001 protein
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms gene 1 organism-gene 4 sequence 1 organism-sequence 4 modification 3 organism-modification 5 union 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	IUPHARobj:2045, PIRSF:PIRSF038189

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All gene organism-gene sequence organism-sequence modification organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRAK4 forms found in complexes

IRAK4 Component Complexes PR:000001780 IRAK4 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex PR:000027181 mIRAK4/UnMod PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:000027181 mIRAK4/UnMod PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse) PR:000027181 mIRAK4/UnMod PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:000027184 hIRAK4/UnMod PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human) PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) PR:Q8R4K2 mIRAK4 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894

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