PRO Entry Report - PR:000001811

Protein Forms Annotations

Ontology Information

PRO ID

PR:000001811 Show OBO stanza / PAF

PRO name

DNA-binding protein Ikaros

Synonyms

PRO-short-label:	EXACT:	IKZF1
Gene-based:	RELATED:	IK1 \| IKAROS \| LYF1 \| ZNFN1A1 \| Zfpn1a1
Other:	EXACT:	Ikaros family zinc finger protein 1 \| lymphoid transcription factor LyF-1

Definition

An Ikaros-like zinc finger transcription factor that is a translation product of the human IKZF1 gene or a 1:1 ortholog thereof. [PRO:WCB]

PRO Category

gene

Parent

PR:000002986 Ikaros-like zinc finger transcription factor

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:Q03267-1 mIKZF1/iso:VI	acts_upstream_of_or_within	GO:0000122 negative regulation of transcription by RNA polymerase II	PMID:12617992
	acts_upstream_of_or_within	GO:0001779 natural killer cell differentiation	PMID:7923373
	acts_upstream_of_or_within	GO:0060041 retina development in camera-type eye	MGI:3831471, PMID:18940586
	acts_upstream_of_or_within	GO:0051138 positive regulation of NK T cell differentiation	MGI:1340364, PMID:10366784
	enables	GO:0046982 protein heterodimerization activity with PR:Q8C208-1 mIKZF4/iso:1	MGI:1333610, PMID:10218586
	enables	GO:0046982 protein heterodimerization activity with PR:P81183-1\|PR:P81183-2	MGI:1203354, PMID:9560339
	located_in	GO:0005634 nucleus	MGI:2652944, PMID:12617992

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:Q03267-1 mIKZF1/iso:VI	MGI:2652944, PMID:12617992

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