PRO Entry Report - PR:000002049

Protein Ontology Report - IRF7

PR:000002049 - http://purl.obolibrary.org/obo/PR_000002049

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000002049 Show OBO stanza / PAF

PRO name

interferon regulatory factor 7

Synonyms

PRO-short-label:	EXACT:	IRF7
Other:	EXACT:	IRF-7

Definition

An interferon regulatory factor 3-9 that is a translation product of the human IRF7 gene or a 1:1 ortholog thereof. [PRO:WCB]

PRO Category

gene

Parent

PR:000001863 interferon regulatory factor 3-9

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	2
sequence	1	organism-sequence	4
modification	4	organism-modification	5
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

IRF7 forms found in complexes

IRF7 Component	Complexes
PR:000027082 hIRF7/iso:1/Phos:1	PR:000027086 IRF7-P:IRF7-P complex (human)
PR:000027082 hIRF7/iso:1/Phos:1	PR:000027084 IRF3-P:IRF7-P complex (human)
PR:000028704 hIRF7/UnMod	PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028704 hIRF7/UnMod	PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028704 hIRF7/UnMod	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028704 hIRF7/UnMod	PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
	enables	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_27000
	located_in	GO:0010008 endosome membrane	Reactome:REACT_27000
PR:000037791 hIRF7/iso:1/UnPhos:1 Ser-477/Ser-479, PR:000026291	located_in	GO:0005737 cytoplasm	Reactome:REACT_21735
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
PR:000027086 IRF7-P:IRF7-P complex (human)	acts_upstream_of_or_within	GO:0034142 toll-like receptor 4 signaling pathway	Reactome:REACT_6894
	acts_upstream_of_or_within	GO:0002753 cytosolic pattern recognition receptor signaling pathway	Reactome:REACT_7146
	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
	enables	GO:0003700 DNA-binding transcription factor activity	PMID:11073981
	located_in	GO:0005654 nucleoplasm	Reactome:REACT_21689
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
	enables	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_27000
	located_in	GO:0010008 endosome membrane	Reactome:REACT_27000

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005654 nucleoplasm	PR:000027086 IRF7-P:IRF7-P complex (human)	Reactome:REACT_21689
GO:0010008 endosome membrane	PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_27000
	PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_27000
	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
GO:0005737 cytoplasm	PR:000037791 hIRF7/iso:1/UnPhos:1 Ser-477/Ser-479, PR:000026291	Reactome:REACT_21735

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