| PRO ID |
PR:000003068
Show OBO stanza
|
| PRO name |
tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 |
| Synonyms |
| PRO-short-label: |
EXACT: |
ZAP70/iso:1/Phos:1 |
| Other: |
EXACT: |
ZAP-70 activated | ZAP-70 active form |
|
| Definition |
A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form in which the phosphorylation occurs on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck, following TCR engagement. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. It has been shown that Tyr-319 in the human sequence is required for the positive regulation of ZAP-70 function.
[PMID:10037717, PRO:CL]
|
| PRO Category |
modification |
| Parent |
PR:000003067 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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