PRO Entry Report - PR:000003436

Protein Forms Annotations

Ontology Information

PRO ID

PR:000003436 Show OBO stanza / PAF

PRO name

E3 SUMO-protein ligase PIAS2

Synonyms

PRO-short-label:	EXACT:	PIAS2
Gene-based:	RELATED:	PIASX
Other:	EXACT:	ARIP3 \| Msx-interacting zinc finger protein \| PIAS-NY protein \| androgen receptor-interacting protein 3 \| miz1 \| protein inhibitor of activated STAT x \| protein inhibitor of activated STAT2
	RELATED:	DAB2-interacting protein \| DIP

Definition

An E3 SUMO-protein ligase PIAS that is a translation product of the human PIAS2 gene or a 1:1 ortholog thereof. [MGI:1096566, PRO:HJD]

PRO Category

gene

Parent

PR:000003444 E3 SUMO-protein ligase PIAS

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:Q8C5D8-2 mPIAS2/iso:2	acts_upstream_of_or_within	GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:1929027, PMID:11104669
PR:Q8C5D8-2 mPIAS2/iso:2	enables	GO:0005515 protein binding with PR:P98078-3 mDAB2/iso:3	MGI:1929027, PMID:11104669
PR:Q8C5D8-1 mPIAS2/iso:1	acts_upstream_of_or_within	GO:0006351 DNA-templated transcription	MGI:894957, PMID:9256341
	acts_upstream_of_or_within	GO:0045667 regulation of osteoblast differentiation	MGI:3723333, PMID:17623776
	acts_upstream_of_or_within	GO:0016925 protein sumoylation	PMID:15767674
	acts_upstream_of_or_within	GO:0045893 positive regulation of DNA-templated transcription	MGI:3723333, PMID:17623776
	acts_upstream_of_or_within	GO:0006357 regulation of transcription by RNA polymerase II	MGI:894957, PMID:9256341
	enables	GO:0019789 SUMO transferase activity	PMID:15767674
	enables	GO:0003677 DNA binding	MGI:894957, PMID:9256341
	enables	GO:0005515 protein binding with PR:P29037 mTBP	PMID:16522640
	enables	GO:0005515 protein binding with PR:P08152-2 mEGR2/iso:Short	MGI:3629292, PMID:16675951
	located_in	GO:0005634 nucleus	PMID:16522640
	located_in	GO:0016604 nuclear body	MGI:3629292, PMID:16675951

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0016604 nuclear body	PR:Q8C5D8-1 mPIAS2/iso:1	MGI:3629292, PMID:16675951
GO:0005634 nucleus	PR:Q8C5D8-1 mPIAS2/iso:1	PMID:16522640

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