PRO Entry Report - PR:000007204

Protein Forms Annotations

Ontology Information

PRO ID

PR:000007204 Show OBO stanza / PAF

PRO name

estrogen receptor

Synonyms

PRO-short-label:	EXACT:	ESR1
Gene-based:	RELATED:	ESR \| Estr \| Estra \| NR3A1
Other:	EXACT:	ER \| ER-alpha \| estradiol receptor \| nuclear receptor subfamily 3 group A member 1

Definition

A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof. [PRO:DNx]

PRO Category

gene

Parent

Terms by PRO Category

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Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	IUPHARobj:620

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000027726 hESR1/iso:1/Phos:2 Tyr-52/Tyr-219, MOD:00048	acts_upstream_of_or_within	GO:0010628 positive regulation of gene expression	PMID:20101225
	enables	GO:0042803 protein homodimerization activity	PMID:20101225
	located_in	GO:0005634 nucleus	PMID:20101225
PR:000027756 hESR1/iso:1/Ac:1 Lys-266/Lys-268, MOD:00064	enables	GO:0003677 DNA binding	PMID:16497729
PR:000027724 hESR1/iso:1/Phos:1 Ser-167, MOD:00046	acts_upstream_of_or_within	GO:0045893 positive regulation of DNA-templated transcription	PMID:19940156
PR:000027776 hESR1/iso:1/Phos:4 Thr-311, MOD:00047	acts_upstream_of_or_within	GO:0010628 positive regulation of gene expression	PMID:12138194
PR:000027776 hESR1/iso:1/Phos:4 Thr-311, MOD:00047	located_in	GO:0005634 nucleus	PMID:12138194

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:000027726 hESR1/iso:1/Phos:2 Tyr-52/Tyr-219, MOD:00048	PMID:20101225
GO:0005634 nucleus	PR:000027776 hESR1/iso:1/Phos:4 Thr-311, MOD:00047	PMID:12138194

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