PRO Entry Report - PR:000016567

Protein Ontology Report - TP63

PR:000016567 - http://purl.obolibrary.org/obo/PR_000016567

Protein Forms Annotations

Ontology Information

PRO ID

PR:000016567 Show OBO stanza / PAF

PRO name

tumor protein 63

Synonyms

PRO-short-label:	EXACT:	TP63
Gene-based:	RELATED:	KET \| P73H \| P73L \| TP73L \| Trp63
Other:	EXACT:	CUSP \| chronic ulcerative stomatitis protein \| keratinocyte transcription factor KET \| p73L \| transformation-related protein 63 \| tumor protein p73-like
	BROAD:	p40 \| p51 \| p63

Definition

A protein that is a translation product of the human TP63 gene or a 1:1 ortholog thereof. [PRO:DNx]

PRO Category

gene

Parent

PR:000000001 protein

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	3
sequence	6	organism-sequence	27
modification	0	organism-modification	0
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000044373 tumor protein 63 DeltaN isoform (mouse)	acts_upstream_of_or_within	GO:0048745 smooth muscle tissue development	MGI:3703103, PMID:17079275
	acts_upstream_of_or_within	GO:0060157 urinary bladder development	MGI:3703103, PMID:17079275
	acts_upstream_of_or_within	GO:0002053 positive regulation of mesenchymal cell proliferation	MGI:3703103, PMID:17079275
	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	MGI:3703103, PMID:17079275
PR:O88898-2 mTP63/iso:2	acts_upstream_of_or_within	GO:0000122 negative regulation of transcription by RNA polymerase II	MGI:3623698, PMID:16618808
	acts_upstream_of_or_within	GO:0045617 negative regulation of keratinocyte differentiation	MGI:3623698, PMID:16618808
	acts_upstream_of_or_within	GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:3696305, PMID:17093266
	acts_upstream_of_or_within	GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:2664466, PMID:12789272
	acts_upstream_of_or_within	GO:0000122 negative regulation of transcription by RNA polymerase II	MGI:3623698, PMID:16618808
	acts_upstream_of_or_within	GO:0008544 epidermis development	MGI:3761221, PMID:16601749
	acts_upstream_of_or_within	GO:0043616 keratinocyte proliferation	MGI:3761221, PMID:16601749
	acts_upstream_of_or_within	GO:0002064 epithelial cell development	MGI:3761221, PMID:16601749
	acts_upstream_of_or_within	GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:3761221, PMID:16601749
	acts_upstream_of_or_within	GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:3794467, PMID:18326838
	enables	GO:0003682 chromatin binding	MGI:3761221, PMID:16601749
	enables	GO:0043565 sequence-specific DNA binding	MGI:3623698, PMID:16618808
	enables	GO:0043565 sequence-specific DNA binding	MGI:3794467, PMID:18326838
	located_in	GO:0005634 nucleus	MGI:3761221, PMID:16601749
PR:O88898-1 mTP63/iso:1	acts_upstream_of_or_within	GO:0008544 epidermis development	MGI:3761221, PMID:16601749
PR:O88898-1 mTP63/iso:1	located_in	GO:0005634 nucleus	MGI:3761221, PMID:16601749

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:O88898-1 mTP63/iso:1	MGI:3761221, PMID:16601749
GO:0005634 nucleus	PR:O88898-2 mTP63/iso:2	MGI:3761221, PMID:16601749

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