back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 PRO tracker
 PRO Consortium

Protein Ontology Report - IRF3-P:IRF3-P complex

PR:000025764 -
Ontology Information
PRO ID PR:000025764 Show OBO stanza / PAF
PRO name IRF3-P:IRF3-P complex
Other: EXACT: IRF3pIRF3p
Definition A protein-containing complex that is composed of a dimer of phosphorylated IRF-3. [PRO:CNA, TLR:AMM]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 2
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000027098 PR:000027097 interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse) mIRF3/iso:1/Phos:1 An interferon regulatory factor 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70671-1, Ser-378/Ser-379, MOD:00046. [PMID:12872135, PRO:CNA] 2
PR:000025765 PR:000045488 interferon regulatory factor 3 phosphorylated 1 (human) hIRF3/Phos:1 An interferon regulatory factor 3 (human) that has been phosphorylated in Ser and Thr residues within the two phosphorylation cluster sites. A Ser (Ser-386 in UniProtKB:Q14653-1) on the 2S site and multiple Ser and Thr residues in the 5ST site (Ser-396, Ser-498, Ser-402, Thr-404, and Ser-405 in UniProtKB:Q14653-1). Example: UniProtKB:Q14653-1, Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047. [PRO:CNA, Reactome:R-HSA-166258, Reactome:R-HSA-177654] 2

Functional Annotation
PRO Term GO Annotation Evidence
IRF3-P:IRF3-P complex (human)
acts_upstream_of_or_within GO:0002753 cytosolic pattern recognition receptor signaling pathway Reactome:REACT_7146
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
acts_upstream_of_or_within GO:0034340 response to type I interferon PMID:10805757
located_in GO:0005654 nucleoplasm Reactome:REACT_7444
located_in GO:0005634 nucleus PMID:10805757
located_in GO:0005829 cytosol Reactome:REACT_7146
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025765 IRF3-P:IRF3-P complex (human)

GO:0005654 nucleoplasm PR:000025765 IRF3-P:IRF3-P complex (human)

GO:0005829 cytosol PR:000025765 IRF3-P:IRF3-P complex (human)