| PRO ID |
PR:000025796
Show OBO stanza
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| PRO name |
integrin alpha |
| Definition |
A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif.
[PMID:19693543]
|
| Comment |
Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. |
| PRO Category |
family |
| Parent |
PR:000000001 protein |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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