PRO Entry Report - PR:000025937

Protein Ontology Report - hSMAD2/iso:Long/Phos:4

PR:000025937 - http://purl.obolibrary.org/obo/PR_000025937

Protein Forms Annotations

Ontology Information

PRO ID

PR:000025937 Show OBO stanza / PAF / GPI

PRO name

smad2 isoform Long phosphorylated 4 (human)

Synonyms

PRO-short-label:	EXACT:	hSMAD2/iso:Long/Phos:4
PRO-proteoform-std:	EXACT:	UniProtKB:Q15796-1, Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255, MOD:00046

Definition

A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047, Ser-245/Ser-250/Ser-255, MOD:00046. [PMID:10197981]

Comment

Kinase=("MAP2K1"; PR:000026196; Thr-220/Ser-245/Ser-250/Ser-255).

PRO Category

organism-modification

Parent

PR:000000653 smad2 isoform Long phosphorylated 4

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000025937 hSMAD2/iso:Long/Phos:4 Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255, MOD:00046	enables	NOT GO:0003713 transcription coactivator activity	PMID:10197981
	located_in	GO:0005737 cytoplasm	PMID:10197981

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005737 cytoplasm	PR:000025937 hSMAD2/iso:Long/Phos:4 Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255, MOD:00046	PMID:10197981

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