PRO Entry Report - PR:000027808

Protein Ontology Report - hTP53/iso:1/Me:3

PR:000027808 - http://purl.obolibrary.org/obo/PR_000027808

Protein Forms Annotations

Ontology Information

PRO ID

PR:000027808 Show OBO stanza / PAF / GPI

PRO name

cellular tumor antigen p53 isoform 1 methylated 3 (human)

Synonyms

PRO-short-label:	EXACT:	hTP53/iso:1/Me:3
PRO-proteoform-std:	EXACT:	UniProtKB:P04637-1, Lys-372, MOD:00663
Other:	EXACT:	p53-mLys372

Definition

A cellular tumor antigen p53 isoform 1 methylated 3 in human. This modification promotes p53 stability and inhibits Smyd2 mediated p53 methylation at Lys-370. UniProtKB:P04637-1, Lys-372, MOD:00663. [PMID:15525938, PRO:PD]

Comment

Methylase=("SETD7"; PR:Q8WTS6; Lys-372).

PRO Category

organism-modification

Parent

PR:000027807 cellular tumor antigen p53 isoform 1 methylated 3

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000027808 hTP53/iso:1/Me:3 Lys-372, MOD:00663	acts_upstream_of_or_within	GO:0045893 positive regulation of DNA-templated transcription	PMID:15525938
PR:000027808 hTP53/iso:1/Me:3 Lys-372, MOD:00663	located_in	GO:0005634 nucleus	PMID:15525938

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:000027808 hTP53/iso:1/Me:3 Lys-372, MOD:00663	PMID:15525938

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