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Protein Ontology Report - NRG1

PR:000029649 - http://purl.obolibrary.org/obo/PR_000029649
Ontology Information
PRO ID PR:000029649 Show OBO stanza / PAF
PRO name pro-neuregulin-1, membrane-bound isoform
Synonyms
PRO-short-label: EXACT: NRG1
Gene-based: RELATED: GGF | HGL | HRGA | NDF | SMDF
Other: EXACT: ARIA | acetylcholine receptor inducing activity | glial growth factor | heregulin | neu differentiation factor | pro-NRG1 | sensory and motor neuron derived factor
Definition A protein that is a translation product of the human NRG1 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 7 organism-sequence 35
modification 2 organism-modification 8
union 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000044824
mNRG1/iso:IIIbeta1a/precursor
acts_upstream_of_or_within GO:0045773 positive regulation of axon extension MGI:4461331, PMID:20610754
PR:000044840
mNRG1/iso:III
acts_upstream_of_or_within NOT GO:0048709 oligodendrocyte differentiation MGI:4420197, PMID:18080294
acts_upstream_of_or_within GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling MGI:3796800, PMID:18458158
acts_upstream_of_or_within GO:0031643 positive regulation of myelination MGI:4420197, PMID:18080294
acts_upstream_of_or_within GO:0031643 positive regulation of myelination MGI:3590355, PMID:16129398
acts_upstream_of_or_within GO:2000010 positive regulation of protein localization to cell surface MGI:3796800, PMID:18458158
acts_upstream_of_or_within GO:0001964 startle response MGI:3803029, PMID:18596162
acts_upstream_of_or_within GO:0060999 positive regulation of dendritic spine development MGI:3803029, PMID:18596162
acts_upstream_of_or_within GO:0060999 positive regulation of dendritic spine development MGI:4461331, PMID:20610754
acts_upstream_of_or_within GO:0008366 axon ensheathment MGI:3590355, PMID:16129398
located_in GO:0030673 axolemma MGI:3796800, PMID:18458158
located_in GO:0030424 axon MGI:4461331, PMID:20610754
located_in GO:0030424 axon MGI:3042336, PMID:15044753
located_in GO:0030425 dendrite MGI:4461331, PMID:20610754
located_in GO:0044297 cell body MGI:4461331, PMID:20610754
PR:000044821
mNRG1/iso:Ibeta1a/mature
acts_upstream_of_or_within GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI:3625788, PMID:11116142
located_in GO:0005576 extracellular region MGI:3625788, PMID:11116142
PR:000044843
mNRG1/Clv:intracellular
acts_upstream_of_or_within GO:0045944 positive regulation of transcription by RNA polymerase II MGI:4461331, PMID:20610754
acts_upstream_of_or_within NOT GO:0045773 positive regulation of axon extension MGI:4461331, PMID:20610754
acts_upstream_of_or_within GO:0022008 neurogenesis MGI:4438553, PMID:19781646
acts_upstream_of_or_within GO:0022008 neurogenesis MGI:4438553, PMID:19781646
enables GO:0005515 protein binding with PR:O54941 mSMARCE1 MGI:4438553, PMID:19781646
located_in GO:0005634 nucleus MGI:4461331, PMID:20610754
PR:Q6DR99
mNRG1/iso:IIIbeta1a
acts_upstream_of_or_within GO:0031643 positive regulation of myelination MGI:3042336, PMID:15044753
PR:Q6DR98
mNRG1
acts_upstream_of_or_within NOT GO:0031643 positive regulation of myelination MGI:3042336, PMID:15044753
located_in GO:0009897 external side of plasma membrane MGI:3625788, PMID:11116142
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0030425 dendrite PR:000044840 mNRG1/iso:III

MGI:4461331, PMID:20610754
GO:0030673 axolemma PR:000044840 mNRG1/iso:III

MGI:3796800, PMID:18458158
GO:0044297 cell body PR:000044840 mNRG1/iso:III

MGI:4461331, PMID:20610754
GO:0005576 extracellular region PR:000044821 mNRG1/iso:Ibeta1a/mature

MGI:3625788, PMID:11116142
GO:0005634 nucleus PR:000044843 mNRG1/Clv:intracellular

MGI:4461331, PMID:20610754
GO:0009897 external side of plasma membrane PR:Q6DR98 mNRG1

MGI:3625788, PMID:11116142
GO:0030424 axon PR:000044840 mNRG1/iso:III

MGI:4461331, PMID:20610754
PR:000044840 mNRG1/iso:III

MGI:3042336, PMID:15044753

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