| PRO ID |
PR:000030035
Show OBO stanza
|
| PRO name |
G-protein coupled receptor |
| Synonyms |
| PRO-short-label: |
EXACT: |
fam:GPCR |
| Other: |
BROAD: |
7TM receptor | seven-transmembrane receptor |
|
| Definition |
A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
[IUPHARfam:694, PRO:DAN, Wikipedia:GPCR]
|
| Comment |
Classification based on GRAFS system. [PMID:12761335] |
| PRO Category |
family |
| Parent |
PR:000000001 protein |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
|
