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Protein Ontology Report - hBUB1B/Phos:3

PR:000035432 - http://purl.obolibrary.org/obo/PR_000035432
Ontology Information
PRO ID PR:000035432 Show OBO stanza / PAF / GPI
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)
Synonyms
PRO-short-label: EXACT: hBUB1B/Phos:3
PRO-proteoform-std: NARROW: UniProtKB:O60566-1, Thr-608, MOD:00047
Other: RELATED: BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047. [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]
Comment One of the articles cited mentions BUB1B (PR:O60566) as the kinase when bound to CENPE (PR:Q02224).
PRO Category organism-modification
Parent PR:000035431 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035432
hBUB1B/Phos:3
Thr-608, MOD:00047 		acts_upstream_of_or_within GO:0007059 chromosome segregation increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
acts_upstream_of_or_within GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
acts_upstream_of_or_within GO:0001933 negative regulation of protein phosphorylation decreased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
located_in GO:0000776 kinetochore PMID:22801780
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
PMID:22801780

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