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Protein Ontology Report - activated IkappaB kinase complex

PR:000035832 - http://purl.obolibrary.org/obo/PR_000035832
Ontology Information
PRO ID PR:000035832 Show OBO stanza / PAF
PRO name activated IkappaB kinase complex
Definition An IKK complex where the IKKalpha and beta subunits are phosphorylated in the activation loop. [Reactome:R-HSA-177663]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0008385 IkappaB kinase complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 2
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000035833 PR:Q9Y6K9 NF-kappa-B essential modulator (human) hIKBKG An NF-kappa-B essential modulator that is encoded in the genome of human. [PRO:DNx] 1
PR:000035831 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human) hIKBKB/Phos:1 An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in human. UniProtKB:O14920, Ser-177/Ser-181, MOD:00046. [PRO:DNx, UniProtKB:O14920] 1
PR:000026823 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human) hCHUK/iso:1/Phos:1 An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046. [PRO:CNx] 1
PR:000036119 PR:O88522 NF-kappa-B essential modulator (mouse) mIKBKG An NF-kappa-B essential modulator that is encoded in the genome of mouse. [OMA:O88522, PRO:DNx] 1
PR:000036115 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse) mIKBKB/Phos:1 An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in mouse. Phosphorylation is necessary for activation, and occurs on two Ser residues in the activation loop. UniProtKB:O88351, Ser-177/Ser-181, MOD:00046. [PMID:16751795, PMID:18202307, PRO:CNA, PRO:DAN] 1
PR:000036121 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse) mCHUK/iso:1/Phos:1 An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046. [PMID:16751795, PRO:CNA] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000035833
activated IkappaB kinase complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894

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