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Protein Ontology Report - ticam1:viral dsRNA:TLR3 complex

PR:000037306 - http://purl.obolibrary.org/obo/PR_000037306
Ontology Information
PRO ID PR:000037306 Show OBO stanza / PAF
PRO name ticam1:viral dsRNA:TLR3 complex
Synonyms
Other: EXACT: viral dsRNA:TLR3:TRIF
Definition A macromolecular complex that is composed of viral double stranded RNA (dsRNA), a homodimer of TLR3 and Ticam1 (TRIF). [PRO:CNA, Reactome:R-HSA-168907]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037308 PR:Q80UF7 TIR domain-containing adapter molecule 1 (mouse) mTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of mouse. [OMA:Q80UF7, PRO:CNA] 2
PR:000037789 Toll-like receptor 3, signal peptide removed form (mouse) mTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905. [ECO:0000250, PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1
PR:000037462 PR:A0FKC7 Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta (chicken) chick-TICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of chicken. [PMID:17676477, PRO:CNA, Reactome:R-GGA-433866] 2
PR:Q0PQ88 Toll-like receptor 3 (chicken) chick-TLR3 A Toll-like receptor 3 that is encoded in the genome of chicken. [PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1
PR:000037307 PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037308
ticam1:viral dsRNA:TLR3 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12539043
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:12539043
PR:000037307
ticam1:viral dsRNA:TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783

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