PRO Entry Report - PR:000037329

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000037329 Show OBO stanza / PAF

PRO name

SARM:ticam1:activated TLR3 complex

Synonyms

Other:

EXACT:

SARM:TRIF:activated TLR3 | TLR3TLR3dsRNATrifSARM

Definition

A protein-containing complex that is composed of activated Toll-like receptor 3, TICAM1 (TRIF) and SARM. [PMID:16964262, Reactome:R-HSA-2559578]

Comment

Requested by=TLR.

PRO Category

complex

Parent

GO:0032991 protein-containing complex

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
complex	1	organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000037330	PR:Q8IUC6	TIR domain-containing adapter molecule 1 (human)	hTICAM1	A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA]	2
	PR:Q6SZW1-1	NAD(+) hydrolase SARM1 isoform 1 (human)	hSARM1/iso:1	An NAD(+) hydrolase SARM1 isoform 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q6SZW1]
	PR:000037305	Toll-like receptor 3, signal peptide removed form (human)	hTLR3/SigPep-	A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341]	2
	CHEBI:67208	dsRNA	dsRNA	A double stranded ribonucleic acid. [None]	1

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000037330 SARM:ticam1:activated TLR3 complex (human)	acts_upstream_of_or_within	GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0010008 endosome membrane	PR:000037330 SARM:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783

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