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Protein Ontology Report - SARM:ticam1:activated TLR3 complex

PR:000037329 -
Ontology Information
PRO ID PR:000037329 Show OBO stanza / PAF
PRO name SARM:ticam1:activated TLR3 complex
Other: EXACT: SARM:TRIF:activated TLR3 | TLR3TLR3dsRNATrifSARM
Definition A protein-containing complex that is composed of activated Toll-like receptor 3, TICAM1 (TRIF) and SARM. [PMID:16964262, Reactome:R-HSA-2559578]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037330 PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q6SZW1-1 NAD(+) hydrolase SARM1 isoform 1 (human) hSARM1/iso:1 An NAD(+) hydrolase SARM1 isoform 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q6SZW1]
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1

Functional Annotation
PRO Term GO Annotation Evidence
SARM:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037330 SARM:ticam1:activated TLR3 complex (human)