back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 PRO tracker
 PRO Consortium

Protein Ontology Report - pUbtraf6:ticam1:activated TLR3 complex

PR:000037339 -
Ontology Information
PRO ID PR:000037339 Show OBO stanza / PAF
PRO name pUbtraf6:ticam1:activated TLR3 complex
Other: RELATED: activated TLR3:TRAM:TRIF:K63-pUb-TRAF6
Definition A protein-containing complex that is composed of polyubiquitinated traf6, ticam1, and activated TLR3 complex. Ubiquitin is attached to TRAF6 through an isopeptide bond between the C-terminus of ubiquitin and the epsilon-amino group of a Lys residue in the target protein. [Reactome:R-HSA-936965]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037340 PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human) hTRAF6/K63polyUbiq:1 A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772. [PRO:DAN, UniProtKB:Q9Y4K3] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1

Functional Annotation
PRO Term GO Annotation Evidence
pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)