Protein Ontology Report - HbA1c PR:000050469 - http://purl.obolibrary.org/obo/PR_000050469

Ontology Information
PRO ID	PR:000050469 Show OBO stanza
PRO name	hemoglobin A1c
Synonyms	PRO-short-label: EXACT: HbA1c Other: EXACT: HgbA1c BROAD: glycated hemoglobin | glycohemoglobin
Definition	A hemoglobin complex that is composed of at least one beta-N-1-deoxy fructosyl hemoglobin subunit, in which the glycan is attached to the N-terminal valine (after initiator methionine removal) of one or both beta subunits. [PMID:9732983, PRO:DAN, Wikipedia:Glycated_hemoglobin]
Comment	Note: The precise definition of hemoglobin A1c has evolved over time [https://medcraveonline.com/JNMR/laboratory-diagnosis-of-hba1c-a-review.html]. This PRO term is based on the most-precise definition currently in use.
PRO Category	complex
Parent	GO:0005833 hemoglobin complex
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms complex 1 organism-complex 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000050469 PR:000050468 hemoglobin subunit beta N-1-deoxyfructosylated 1 HBB/InitMet-/dFruc:1 A hemoglobin subunit beta, initiator methionine removed form that has been N-1-deoxyfructosylated at the position equivalent to Val-2 of the sequence represented by UniProtKB:P68871-1 or a 1:1 ortholog thereof. [PRO:DAN] 1 PR:000050468 hemoglobin subunit beta N-1-deoxyfructosylated 1 HBB/InitMet-/dFruc:1 A hemoglobin subunit beta, initiator methionine removed form that has been N-1-deoxyfructosylated at the position equivalent to Val-2 of the sequence represented by UniProtKB:P68871-1 or a 1:1 ortholog thereof. [PRO:DAN] 2 PR:000050026 hemoglobin subunit beta HBB A beta-globin that is a translation product of the human HBB gene or a 1:1 ortholog thereof. [PRO:DAN] 1 PR:000008456 hemoglobin subunit alpha HBA[1/2] A hemoglobin subunit that is a translation product of the human HBA1 or HBA2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. [PRO:DNx] 2

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