PRO Entry Report - PR:P01375

This page represents a class of proteins encompassing all the protein products of the TNF gene in Homo sapiens.

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:P01375 Show OBO stanza / PAF / GPI

PRO name

tumor necrosis factor (human)

Synonyms

PRO-short-label:	EXACT:	hTNF
Gene-based:	RELATED:	TNF \| TNFA \| TNFSF2
Other:	EXACT:	TNF-a (human) \| TNF-alpha (human) \| TNFa (human) \| cachectin (human) \| tumor necrosis factor ligand superfamily member 2 (human)

Definition

A tumor necrosis factor that is encoded in the genome of human. [PRO:DNx]

Comment

Requested by=PubChem.

PRO Category

organism-gene

Parent

PR:000000134 tumor necrosis factor

Gene Template

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	Reactome:R-HSA-66220, UniProtKB:P01375

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

hTNF forms found in complexes

hTNF Component	Complexes
PR:P01375 hTNF	PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000036508 hTNF/iso:1/Phos:1 Ser-2, MOD:00046	located_in	GO:0016020 membrane	PMID:10205166
PR:P01375-1 hTNF/iso:1	acts_upstream_of_or_within	GO:0006915 apoptotic process	PMID:3856324
PR:P01375-1 hTNF/iso:1	located_in	GO:0005886 plasma membrane	PMID:3349526
PR:000036504 hTNF/iso:1/Clv:1	acts_upstream_of_or_within	GO:0006915 apoptotic process	PMID:3856324
	enables	GO:0005164 tumor necrosis factor receptor binding with PR:P19438 hTNFRSF1A	PMID:14512626
	enables	GO:0042802 identical protein binding with PR:000036504 hTNF/iso:1/Clv:1	PMID:14512626
PR:000036507 hTNF/iso:1/Myr:1 Lys-19/Lys-20, MOD:00087	located_in	GO:0016020 membrane	PMID:1402651

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