Protein Ontology Report - hIRF7 PR:Q92985 - http://purl.obolibrary.org/obo/PR_Q92985

This page represents a class of proteins encompassing all the protein products of the IRF7 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q92985 Show OBO stanza / PAF / GPI
PRO name	interferon regulatory factor 7 (human)
Synonyms	PRO-short-label: EXACT: hIRF7 Gene-based: RELATED: IRF7 Other: EXACT: IRF-7 (human)
Definition	An interferon regulatory factor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92985]
PRO Category	organism-gene
Parent	PR:000002049 interferon regulatory factor 7
Gene Template	HGNC:6122 IRF7
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 4 organism-modification 5
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-450274, Reactome:R-HSA-450281, UniProtKB:Q92985

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIRF7 forms found in complexes

hIRF7 Component Complexes PR:000027082 hIRF7/iso:1/Phos:1 PR:000027086 IRF7-P:IRF7-P complex (human) PR:000027082 hIRF7/iso:1/Phos:1 PR:000027084 IRF3-P:IRF7-P complex (human) PR:000028704 hIRF7/UnMod PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000028704 hIRF7/UnMod PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000028704 hIRF7/UnMod PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000028704 hIRF7/UnMod PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000037791 hIRF7/iso:1/UnPhos:1 Ser-477/Ser-479, PR:000026291 located_in GO:0005737 cytoplasm Reactome:REACT_21735 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000027086 IRF7-P:IRF7-P complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 acts_upstream_of_or_within GO:0002753 cytosolic pattern recognition receptor signaling pathway Reactome:REACT_7146 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0003700 DNA-binding transcription factor activity PMID:11073981 located_in GO:0005654 nucleoplasm Reactome:REACT_21689 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005654 nucleoplasm PR:000027086 IRF7-P:IRF7-P complex (human) Reactome:REACT_21689 GO:0010008 endosome membrane PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0005737 cytoplasm PR:000037791 hIRF7/iso:1/UnPhos:1 Ser-477/Ser-479, PR:000026291 Reactome:REACT_21735

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