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Protein Ontology Report - NOG

PR:000000021 - http://purl.obolibrary.org/obo/PR_000000021
Ontology Information
PRO ID PR:000000021 Show OBO stanza / PAF
PRO name noggin
Synonyms
PRO-short-label: EXACT: NOG
Definition A protein that is a translation product of the human NOG gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 12
modification 2 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000116
hNOG/var:Y222D
Tyr-222, CHEBI:29958 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:10080184
PR:000000114
hNOG/var:I220N
Ile-220, CHEBI:50347 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:10080184
PR:000000115
hNOG/var:Y222C
Tyr-222, CHEBI:29950 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:11545688
associated_with_disease_progression DOID:0050789 tarsal-carpal coalition syndrome PMID:10080184
PR:000000112
hNOG/var:R204L
Arg-204, CHEBI:30006 		associated_with_disease_progression DOID:0050789 tarsal-carpal coalition syndrome PMID:11545688
PR:000000110
hNOG/var:C184Y
Cys-184, CHEBI:46858 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:11846737
PR:000000107
hNOG/var:P35S
Pro-35, CHEBI:29999 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:11857750
PR:000000111
hNOG/var:G189C
Gly-189, CHEBI:29950 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:99178269
PR:000000109
hNOG/var:P35R
Pro-35, CHEBI:29952 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:11545688
associated_with_disease_progression DOID:0050789 tarsal-carpal coalition syndrome PMID:11545688
PR:000000108
hNOG/var:P223L
Pro-223, CHEBI:30006 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:10080184
PR:000000021
NOG
acts_upstream_of_or_within GO:0030514 negative regulation of BMP signaling pathway PANTHER:PTHR10494:SF2, PIRSF:PIRSF008129, UniProtKB:P97466, UniProtKB:Q13253
acts_upstream_of_or_within GO:0007275 multicellular organism development PANTHER:PTHR10494:SF2, PIRSF:PIRSF008129, UniProtKB:P97466, UniProtKB:Q13253
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PANTHER:PTHR10494:SF2, PIRSF:PIRSF008129, UniProtKB:P97466, UniProtKB:Q13253
PR:000036421
hNOG/iso:1/SigPep-
acts_upstream_of_or_within GO:0030514 negative regulation of BMP signaling pathway PMID:12478285
enables GO:0005515 protein binding with PR:000036517 hBMP7/iso:1/mature/NGlyco:1 PMID:12478285
located_in GO:0005615 extracellular space PMID:11562478
PR:P97466-1
mNOG/iso:1
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:15110716
PR:000000113
hNOG/var:W217G
Trp-217, CHEBI:29947 		associated_with_disease_progression DOID:0050788 proximal symphalangism PMID:10080184
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000036421 hNOG/iso:1/SigPep-

PMID:11562478

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