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Protein Ontology Report - TNF

PR:000000134 - http://purl.obolibrary.org/obo/PR_000000134
Ontology Information
PRO ID PR:000000134 Show OBO stanza / PAF
PRO name tumor necrosis factor
Synonyms
PRO-short-label: EXACT: TNF
Gene-based: RELATED: TNFA | TNFSF2
Other: EXACT: TNF-a | TNF-alpha | TNFa | cachectin | tumor necrosis factor alpha | tumor necrosis factor ligand superfamily member 2
Definition A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. [PMID:11053079, PRO:CNA]
PRO Category gene
Parent PR:000000033 tumor necrosis factor, TNF-like
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 2
modification 7 organism-modification 7
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TNF forms found in complexes
TNF Component Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:P01375-1
hTNF/iso:1
acts_upstream_of_or_within GO:0006915 apoptotic process PMID:3856324
located_in GO:0005886 plasma membrane PMID:3349526
PR:000036504
hTNF/iso:1/Clv:1
acts_upstream_of_or_within GO:0006915 apoptotic process PMID:3856324
enables GO:0042802 identical protein binding with PR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
enables GO:0005164 tumor necrosis factor receptor binding with PR:P19438 hTNFRSF1A PMID:14512626
PR:000036505
mTNF/iso:1/Clv:1
acts_upstream_of_or_within GO:0006355 regulation of DNA-templated transcription PMID:9305915
located_in GO:0005615 extracellular space PMID:10089307
PR:000036506
mTNF/iso:1/Clv:2
enables NOT GO:0005125 cytokine activity PMID:2777790
located_in GO:0005576 extracellular region PMID:2777790
PR:000036507
hTNF/iso:1/Myr:1
Lys-19/Lys-20, MOD:00087 		located_in GO:0016020 membrane PMID:1402651
PR:000036508
hTNF/iso:1/Phos:1
Ser-2, MOD:00046 		located_in GO:0016020 membrane PMID:10205166
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005576 extracellular region PR:000036506 mTNF/iso:1/Clv:2

PMID:2777790
GO:0016020 membrane PR:000036507 hTNF/iso:1/Myr:1
Lys-19/Lys-20, MOD:00087
PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1
Ser-2, MOD:00046
PMID:10205166
GO:0005886 plasma membrane PR:P01375-1 hTNF/iso:1

PMID:3349526
GO:0005615 extracellular space PR:000036505 mTNF/iso:1/Clv:1

PMID:10089307

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