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Protein Ontology report - mothers against decapentaplegic homolog 3 (human)
PR:P84022 - http://purl.obolibrary.org/obo/PR_P84022
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:P84022   
  PRO namemothers against decapentaplegic homolog 3 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD3
Gene-based: RELATED:MADH3 | SMAD3
Other: EXACT:hMAD-3 | JV15-2 (human) | MAD homolog 3 (human) | Mad3 (human) | mothers against DPP homolog 3 (human) | SMAD 3 (human) | SMAD family member 3 (human) | Smad3 (human)
  Definition"A smad3 that is encoded in the genome of human." [] 
  PRO Categoryorganism-gene 
  ParentPR:000000365 smad3
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6769 SMAD3 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 15                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P84022
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P84022 mothers against decapentaplegic homolog 3 (human)
hSMAD3

organism-sequence


PR:000062539 mothers against decapentaplegic homolog 3 sequence variant S425F (human)
hSMAD3/var:S425F

organism-sequence


PR:000063486 mothers against decapentaplegic homolog 3 sequence variant S425C (human)
hSMAD3/var:S425C

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human)
hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:P84022-2 mothers against decapentaplegic homolog 3 isoform h2 (human)
hSMAD3/iso:h2

organism-sequence


PR:P84022-3 mothers against decapentaplegic homolog 3 isoform h3 (human)
hSMAD3/iso:h3

organism-sequence


PR:P84022-4 mothers against decapentaplegic homolog 3 isoform h4 (human)
hSMAD3/iso:h4

organism-modification


PR:000049285 mothers against decapentaplegic homolog 3 phosphorylated 1 (human)
hSMAD3/Phos:1

organism-modification


PR:000049286 mothers against decapentaplegic homolog 3 phosphorylated 2 (human)
hSMAD3/Phos:2

organism-modification


PR:000049287 mothers against decapentaplegic homolog 3 ubiquitinated form (human)
hSMAD3/UbiqLys+

organism-modification


PR:000064859 mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human)
hSMAD3/PhosUbiq:1

organism-modification


PR:000060563 mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human)
hSMAD3/var:R268H/Phos:1

organism-modification


PR:000061858 mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human)
hSMAD3/ADPribPhos:1

organism-modification


PR:000063368 mothers against decapentaplegic homolog 3 phosphorylated 3 (human)
hSMAD3/Phos:3

organism-modification


PR:000063580 mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human)
hSMAD3/var:R268C/Phos:1

organism-modification


PR:000063639 mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human)
hSMAD3/var:D258N/Phos:1

organism-modification


PR:000065228 mothers against decapentaplegic homolog 3 deaminated 1 (human)
hSMAD3/Deam:1

organism-modification


PR:000065534 mothers against decapentaplegic homolog 3 methylated 1 (human)
hSMAD3/Me:1

organism-modification


PR:000073148 mothers against decapentaplegic homolog 3 cysteinylated 1 (human)
hSMAD3/Cyst:1

organism-modification


PR:000074741 mothers against decapentaplegic homolog 3 methylated 2 (human)
hSMAD3/Me:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026333 hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046		 acts_upstream_of_or_withinGO:0006366 transcription by RNA polymerase II PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881; PMID:9380693
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15084259
GO:0046332 SMAD binding PMID:15350224; PMID:9311995
located_inGO:0005634 nucleus PMID:10846168; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
PR:000036557 hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003700 DNA-binding transcription factor activity PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:P84022-1 hSMAD3/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
enablesGO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:O95405-1 PMID:12154125
located_inGO:0005737 cytoplasm PMID:17074053