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Protein Ontology report - E3 ubiquitin ligase SFC complex Skp1 subunit
PR:000000002 - http://purl.obolibrary.org/obo/PR_000000002
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000002   
  PRO nameE3 ubiquitin ligase SFC complex Skp1 subunit 
  DefinitionA protein that has a core domain composition consisting of an N-terminal Skp1 family, tetramerisation domain (Pfam:PF03931) followed by a Skp1 family, dimerisation domain (Pfam:PF01466). Skp1 proteins bind several F-box-containing proteins, and are involved in the ubiquitin protein degradation pathway. [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF028729
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000002 E3 ubiquitin ligase SFC complex Skp1 subunit
E3 ubiquitin ligase SFC complex Skp1 subunit
Yes
gene


PR:000000045 S-phase kinase-associated protein 1A
SKP1

organism-gene


PR:P52286 suppressor of kinetochore protein 1 (yeast)
ySKP1

organism-gene


PR:P63208 S-phase kinase-associated protein 1 (human)
hSKP1

organism-sequence


PR:P63208-1 S-phase kinase-associated protein 1 isoform 1 (human)
hSKP1/iso:1
Yes
organism-sequence


PR:P63208-2 S-phase kinase-associated protein 1 isoform 2 (human)
hSKP1/iso:2

organism-modification


PR:000026755 S-phase kinase-associated protein 1A, initiator methionine removed form (human)
hSKP1/InitMet-

Yes
organism-modification


PR:000066666 S-phase kinase-associated protein 1 methylated 1 (human)
hSKP1/Me:1

organism-modification


PR:000067768 S-phase kinase-associated protein 1 deaminated 1 (human)
hSKP1/Deam:1

organism-modification


PR:000082662 S-phase kinase-associated protein 1 deaminated 2 (human)
hSKP1/Deam:2

organism-gene


PR:Q5ZKF5 S-phase kinase-associated protein 1 (chicken)
chick-SKP1

organism-gene


PR:Q6PEC4 S-phase kinase-associated protein 1 (rat)
rSKP1

organism-gene


PR:Q9WTX5 S-phase kinase-associated protein 1 (mouse)
mSKP1

organism-sequence


PR:Q9WTX5-1 S-phase kinase-associated protein 1 isoform 1 (mouse)
mSKP1/iso:1
Yes
organism-gene


PR:Q9Y709 suppressor of kinetochore protein 1 (Schizosaccharomyces pombe 972h-)
Spom972h-SKP1

sequence


PR:000000180 S-phase kinase-associated protein 1A isoform 1
SKP1/iso:1

organism-sequence


PR:P63208-1 S-phase kinase-associated protein 1 isoform 1 (human)
hSKP1/iso:1
Yes
organism-sequence


PR:Q9WTX5-1 S-phase kinase-associated protein 1 isoform 1 (mouse)
mSKP1/iso:1
Yes
modification


PR:000026647 S-phase kinase-associated protein 1A isoform 1, initiator methionine removed form
SKP1/iso:1/InitMet-

sequence


PR:000000181 S-phase kinase-associated protein 1A isoform 2
SKP1/iso:2

organism-sequence


PR:P63208-2 S-phase kinase-associated protein 1 isoform 2 (human)
hSKP1/iso:2

modification


PR:000018274 S-phase kinase-associated protein 1A, initiator methionine removed form
SKP1/InitMet-

modification


PR:000026647 S-phase kinase-associated protein 1A isoform 1, initiator methionine removed form
SKP1/iso:1/InitMet-

organism-modification


PR:000026755 S-phase kinase-associated protein 1A, initiator methionine removed form (human)
hSKP1/InitMet-

Yes
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forms found in complexes   

Component
 Complexes
PR:000026755 hSKP1/InitMet- PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000002 E3 ubiquitin ligase SFC complex Skp1 subunit
Skp1 proteins bind several F-box-containing proteins, and are involved in the ubiquitin protein degradation pathway		 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PIRSF:PIRSF028729
located_inGO:0019005 SCF ubiquitin ligase complex PIRSF:PIRSF028729
PR:P63208-1 hSKP1/iso:1 enablesGO:0005515 protein binding with PR:Q13616-1 PMID:12609982
located_inGO:0019005 SCF ubiquitin ligase complex PMID:11961546; PMID:12481031; PMID:16797541; PMID:17098746
PR:Q9WTX5-1 mSKP1/iso:1 enablesGO:0005515 protein binding with PR:P62137-1 PMID:17274640
GO:0005515 protein binding with PR:P63087-1 PMID:17274640
located_inGO:0019005 SCF ubiquitin ligase complex PMID:12665572