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Protein Ontology report - cullin
PR:000000013 - http://purl.obolibrary.org/obo/PR_000000013
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000013   
  PRO namecullin 
  Definition"A protein that has a core domain composition consisting of a cullin domain that functions as a molecular scaffold responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases." [PIRSF:PIRSF017874] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene11                                                  Organism-Gene 33                                        
         Sequence5                                                  Organism-Sequence 25                                        
         Modification3                                                  Organism-Modification 28                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF017874
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000013 cullin
CHRD
Yes
gene


PR:000000092 fungal/metazoan cullin-1
CUL1
Yes
organism-gene


PR:O13790 cullin-1 (Schizosaccharomyces pombe 972h-)
Spom972h-CUL1

organism-gene


PR:O60999 cullin-1 (Dictyostelium discoideum)
Dicty-CUL1

organism-gene


PR:Q12018 cell division control protein 53 (yeast)
yCUL1

organism-gene


PR:Q13616 cullin-1 (human)
hCUL1

Yes
organism-sequence


PR:Q13616-1 cullin-1 isoform 1 (human)
hCUL1/iso:1
Yes
organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
Yes
organism-modification


PR:000064861 cullin-1 neddylated 1 (human)
hCUL1/Nedd:1

organism-modification


PR:000071994 cullin-1 methylated 1 (human)
hCUL1/Me:1

organism-modification


PR:000075174 cullin-1 cysteinylated 1 (human)
hCUL1/Cyst:1

organism-gene


PR:Q17389 cullin-1 (worm)
CUL1 (worm)

organism-gene


PR:Q24311 cullin homolog 1 (fruit fly)
fly-CUL1

organism-gene


PR:Q9WTX6 cullin-1 (mouse)
mCUL1

organism-sequence


PR:Q9WTX6-1 cullin-1 isoform 1 (mouse)
mCUL1/iso:1

sequence


PR:000000267 fungal/metazoan cullin-1 isoform 1
CUL1/iso:1

organism-sequence


PR:Q13616-1 cullin-1 isoform 1 (human)
hCUL1/iso:1
Yes
organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
Yes
organism-sequence


PR:Q9WTX6-1 cullin-1 isoform 1 (mouse)
mCUL1/iso:1

modification


PR:000000427 fungal/metazoan cullin-1 isoform 1 neddylated form
CUL1/iso:1/NeddLys+

modification


PR:000000542 fungal/metazoan cullin-1 isoform 1 neddylated 1
CUL1/iso:1/Nedd:1

organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
Yes
gene


PR:000006047 cullin-2
CUL2

organism-gene


PR:P0CH31 putative cullin-like protein 1 (Arabidopsis thaliana)
At-CUL2

organism-gene


PR:Q13617 cullin-2 (human)
hCUL2

organism-sequence


PR:Q13617-1 cullin-2 isoform 1 (human)
hCUL2/iso:1

organism-sequence


PR:Q13617-2 cullin-2 isoform h2 (human)
hCUL2/iso:h2

organism-modification


PR:000064774 cullin-2 neddylated 1 (human)
hCUL2/Nedd:1

organism-modification


PR:000068780 cullin-2 cysteinylated 1 (human)
hCUL2/Cyst:1

organism-modification


PR:000077772 cullin-2 deaminated 1 (human)
hCUL2/Deam:1

organism-gene


PR:Q17390 cullin-2 (worm)
CUL2 (worm)

organism-sequence


PR:Q17390-1 cullin-2 isoform c (worm)
CUL2/iso:c (worm)

organism-sequence


PR:Q17390-2 cullin-2 isoform b (worm)
CUL2/iso:b (worm)

organism-sequence


PR:Q17390-3 cullin-2 isoform d (worm)
CUL2/iso:d (worm)

organism-gene


PR:Q9D4H8 cullin-2 (mouse)
mCUL2

organism-sequence


PR:Q9D4H8-1 cullin-2 isoform 1 (mouse)
mCUL2/iso:1

organism-sequence


PR:Q9D4H8-2 cullin-2 isoform m2 (mouse)
mCUL2/iso:m2

organism-gene


PR:Q9XZJ3 cullin-2 (Dictyostelium discoideum)
Dicty-CUL2

sequence


PR:000040461 cullin-2 isoform 1
CUL2/iso:1

organism-sequence


PR:Q13617-1 cullin-2 isoform 1 (human)
hCUL2/iso:1

organism-sequence


PR:Q9D4H8-1 cullin-2 isoform 1 (mouse)
mCUL2/iso:1

gene


PR:000006048 cullin-3
CUL3

organism-gene


PR:B5DF89 cullin-3 (rat)
rCUL3

organism-sequence


PR:B5DF89-1 cullin-3 isoform 1 (rat)
rCUL3/iso:1

organism-gene


PR:Q09760 cullin-3 (Schizosaccharomyces pombe 972h-)
Spom972h-CUL3

organism-gene


PR:Q13618 cullin-3 (human)
hCUL3

organism-sequence


PR:Q13618-1 cullin-3 isoform 1 (human)
hCUL3/iso:1

organism-sequence


PR:Q13618-2 cullin-3 isoform h2 (human)
hCUL3/iso:h2

organism-sequence


PR:Q13618-3 cullin-3 isoform h3 (human)
hCUL3/iso:h3

organism-modification


PR:000064684 cullin-3 neddylated 1 (human)
hCUL3/Nedd:1

organism-modification


PR:000067292 cullin-3 methylated 1 (human)
hCUL3/Me:1

organism-modification


PR:000085248 cullin-3 phosphorylated 1 (human)
hCUL3/Phos:1

organism-gene


PR:Q17391 cullin-3 (worm)
CUL3 (worm)

organism-gene


PR:Q54NZ5 cullin-3 (Dictyostelium discoideum)
Dicty-CUL3

organism-gene


PR:Q9JLV5 cullin-3 (mouse)
mCUL3

organism-sequence


PR:Q9JLV5-1 cullin-3 isoform 1 (mouse)
mCUL3/iso:1

organism-modification


PR:000078698 cullin-3 glutathionylated 1 (mouse)
mCUL3/SGlt:1

sequence


PR:000040462 cullin-3 isoform 1
CUL3/iso:1

organism-sequence


PR:B5DF89-1 cullin-3 isoform 1 (rat)
rCUL3/iso:1

organism-sequence


PR:Q13618-1 cullin-3 isoform 1 (human)
hCUL3/iso:1

organism-sequence


PR:Q9JLV5-1 cullin-3 isoform 1 (mouse)
mCUL3/iso:1

gene


PR:000006049 cullin-4A
CUL4A

organism-gene


PR:Q13619 cullin-4A (human)
hCUL4A

organism-sequence


PR:Q13619-1 cullin-4A isoform 1 (human)
hCUL4A/iso:1

organism-sequence


PR:Q13619-2 cullin-4A isoform h2 (human)
hCUL4A/iso:h2

organism-modification


PR:000064856 cullin-4A neddylated 1 (human)
hCUL4A/Nedd:1

organism-modification


PR:000067428 cullin-4A deaminated 1 (human)
hCUL4A/Deam:1

organism-modification


PR:000068427 cullin-4A deaminated 2 (human)
hCUL4A/Deam:2

organism-modification


PR:000075755 cullin-4A cysteinylated 1 (human)
hCUL4A/Cyst:1

organism-modification


PR:000077321 cullin-4A methylated 1 (human)
hCUL4A/Me:1

organism-modification


PR:000080495 cullin-4A methylated 2 (human)
hCUL4A/Me:2

organism-modification


PR:000083127 cullin-4A methylated 3 (human)
hCUL4A/Me:3

organism-gene


PR:Q17392 cullin-4 (worm)
CUL4A (worm)

organism-gene


PR:Q3TCH7 cullin-4A (mouse)
mCUL4A

organism-sequence


PR:Q3TCH7-1 cullin-4A isoform 1 (mouse)
mCUL4A/iso:1

organism-gene


PR:Q54CS2 cullin-4 (Dictyostelium discoideum)
Dicty-CUL4A

sequence


PR:000040463 cullin-4A isoform 1
CUL4A/iso:1

organism-sequence


PR:Q13619-1 cullin-4A isoform 1 (human)
hCUL4A/iso:1

organism-sequence


PR:Q3TCH7-1 cullin-4A isoform 1 (mouse)
mCUL4A/iso:1

gene


PR:000006050 cullin-4B
CUL4B

organism-gene


PR:A2A432 cullin-4B (mouse)
mCUL4B

organism-sequence


PR:A2A432-1 cullin-4B isoform m1 (mouse)
mCUL4B/iso:m1

organism-sequence


PR:A2A432-2 cullin-4B isoform m2 (mouse)
mCUL4B/iso:m2

organism-gene


PR:Q13620 cullin-4B (human)
hCUL4B

organism-sequence


PR:Q13620-1 cullin-4B isoform h2 (human)
hCUL4B/iso:h2

organism-sequence


PR:Q13620-2 cullin-4B isoform h1 (human)
hCUL4B/iso:h1

organism-sequence


PR:Q13620-3 cullin-4B isoform h3 (human)
hCUL4B/iso:h3

organism-modification


PR:000064654 cullin-4B neddylated 1 (human)
hCUL4B/Nedd:1

organism-modification


PR:000071773 cullin-4B methylated 1 (human)
hCUL4B/Me:1

organism-modification


PR:000078291 cullin-4B methylated 2 (human)
hCUL4B/Me:2

organism-modification


PR:000085504 cullin-4B cysteinylated 1 (human)
hCUL4B/Cyst:1

gene


PR:000006051 cullin-5
CUL5

organism-gene


PR:Q23639 cullin-5 (worm)
CUL5 (worm)

organism-gene


PR:Q93034 cullin-5 (human)
hCUL5

organism-sequence


PR:Q93034-1 cullin-5 isoform 1 (human)
hCUL5/iso:1

organism-modification


PR:000046016 cullin-5 phosphorylated 1 (human)
hCUL5/Phos:1

organism-modification


PR:000064753 cullin-5, initiator methionine removed neddylated 1 (human)
hCUL5/InitMet-/Nedd:1

organism-modification


PR:000066894 cullin-5 phosphorylated 2 (human)
hCUL5/Phos:2

organism-modification


PR:000072994 cullin-5 deaminated 1 (human)
hCUL5/Deam:1

organism-modification


PR:000075222 cullin-5 hydroxylated 1 (human)
hCUL5/Hy:1

organism-gene


PR:Q9D5V5 cullin-5 (mouse)
mCUL5

organism-sequence


PR:Q9D5V5-1 cullin-5 isoform 1 (mouse)
mCUL5/iso:1

organism-gene


PR:Q9JJ31 cullin-5 (rat)
rCUL5

organism-sequence


PR:Q9JJ31-1 cullin-5 isoform 1 (rat)
rCUL5/iso:1

sequence


PR:000042373 cullin-5 isoform 1
CUL5/iso:1

organism-sequence


PR:Q93034-1 cullin-5 isoform 1 (human)
hCUL5/iso:1

organism-sequence


PR:Q9D5V5-1 cullin-5 isoform 1 (mouse)
mCUL5/iso:1

organism-sequence


PR:Q9JJ31-1 cullin-5 isoform 1 (rat)
rCUL5/iso:1

gene


PR:000027962 plant cullin-1
plantCUL1

organism-gene


PR:Q94AH6 cullin-1 (Arabidopsis thaliana)
At-CUL1

organism-modification


PR:000027977 cullin-1 rubylated 1 (Arabidopsis thaliana)
At-plantCUL1/Ruby:1

Yes
modification


PR:000027976 plant cullin-1 rubylated 1
plantCUL1/Ruby:1

organism-modification


PR:000027977 cullin-1 rubylated 1 (Arabidopsis thaliana)
At-plantCUL1/Ruby:1

Yes
gene


PR:000028495 plant cullin-3A
CUL3A

organism-gene


PR:Q9ZVH4 cullin-3A (Arabidopsis thaliana)
At-CUL3A

gene


PR:000028497 plant cullin-3B
CUL3B

organism-gene


PR:Q9C9L0 cullin-3B (Arabidopsis thaliana)
At-CUL3B

gene


PR:000028499 plant cullin-4
CUL4

organism-gene


PR:Q8LGH4 cullin-4 (Arabidopsis thaliana)
At-CUL4

Yes
gene


PR:000028501 plant cullin-2
plantCUL2

organism-gene


PR:Q9SRZ0 cullin-2 (Arabidopsis thaliana)
At-plantCUL2

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CHRD forms found in complexes   

CHRD Component
 Complexes
PR:000027977 At-plantCUL1/Ruby:1 PR:000028458 SCF(TIR1) complex (Arabidopsis thaliana)
PR:000028465 SCF(COI1) complex (Arabidopsis thaliana)
PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
PR:Q8LGH4 At-CUL4 PR:000037419 ABD1:DDB1B:CUL4 (Arabidopsis thaliana)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000013 CHRD located_inGO:0031461 cullin-RING ubiquitin ligase complex PIRSF:PIRSF017874
PR:000000092 CUL1 acts_upstream_of_or_withinGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PANTHER:PTHR11932
located_inGO:0019005 SCF ubiquitin ligase complex PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1
UniProtKB:Q13616-1, Lys-720, MOD:01150		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cycle PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathway PMID:8681378
located_inGO:0019005 SCF ubiquitin ligase complex PMID:10713156; PMID:10921923; PMID:17098746
PR:Q13616-1 hCUL1/iso:1 enablesGO:0005515 protein binding with PR:P62877-1 PMID:12504026; PMID:15537541
GO:0005515 protein binding with PR:Q86VP6-1 PMID:12504026; PMID:15537541
located_inNOT GO:0019005 SCF ubiquitin ligase complex PMID:10713156; PMID:10921923; PMID:12504026